ArticleInternational journal of molecular sciences2025
Optimizing the Handling of Cancellous Bone Grafts to Preserve Their Osteogenic Potential in Craniofacial Surgery.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Integrating Additive and Traditional Manufacturing for Multiscale Bone Tissue Engineering Scaffolds.Journal of functional biomaterials · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancellous bone grafts are essential in orthopedic and plastic surgeries due to their osteoconductive and osteoinductive properties. However, handling, storage, and preservation challenges impact their viability and effectiveness in bone healing. This study assessed the effects of handling time, storage temperature, and preservation solutions on bone graft viability and osteogenesis using in vitro and in vivo models. Handling times exceeding 10 min significantly reduced cell viability, with 4 °C storage proving superior to 23 °C and 37 °C. In vivo, grafts stored at 4 °C showed enhanced bone regeneration, with PRP-treated grafts demonstrating greater osteogenic potential compared to those stored in blood or PBS. Micro-CT and histological analyses confirmed superior bone volume and tissue integration with PRP, particularly in older grafts. These findings underscore the importance of optimizing perioperative handling protocols. Storage at 4 °C and preservation in PRP emerge as promising strategies for improving bone graft outcomes in clinical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.