Evidence map›Paper›PMID 40362483›Full record

ArticleInternational journal of molecular sciences2025

Andrés Barba, Laura López-Vilaró, Malena Ferre, Sergio Martinez-Recio, Margarita Majem, Ivana Sullivan, Juliana Salazar

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrés BarbaDepartment of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
Laura López-VilaróDepartment of Pathology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.ORCID 0000-0002-5428-8017
Malena FerreDepartment of Pathology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
Sergio Martinez-RecioDepartment of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.ORCID 0000-0001-8056-7100
Margarita MajemDepartment of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.ORCID 0000-0002-9919-7485
Ivana SullivanDepartment of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.ORCID 0000-0002-0434-3436
Juliana SalazarTranslational Medical Oncology Laboratory, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain.ORCID 0000-0002-3581-4499

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cornerstone of first-line treatment in extensive-stage small cell lung cancer (ES-SCLC) is platinum- and etoposide-based chemotherapy. Platinum compounds could immunomodulate the tumor microenvironment in addition to their cytotoxic effect. Genetic variation in immune checkpoint (IC) pathways may predict chemotherapy efficacy. Polymorphisms in the IC genes were determined, and their association with survival was analyzed in 78 patients with ES-SCLC treated with chemotherapy. PD-L1 protein expression in tumor tissue was determined. Three variants in

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsB7-H1 AntigenLung NeoplasmsPolymorphism, Single NucleotideSmall Cell Lung CarcinomaAdultAgedBiomarkers, TumorCTLA-4 AntigenEtoposideFemaleHumansMaleMiddle AgedPlatinumPrognosisB7-H1 AntigenBiomarkers, TumorCD274 protein, humanCTLA-4 AntigenEtoposidePlatinumbiomarkerCD274 geneextensive-stage small cell lung cancerPD-L1pharmacogeneticsplatinum-based chemotherapy

Identifiers

PMID40362483
PMCPMC12072405

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.