Evidence map›Paper›PMID 40362480›Full record

ArticleInternational journal of molecular sciences2025

Paramutation-Like Behavior of Genic piRNA-Producing Loci in

Alina V Bespalova, Dina A Kulikova, Elena S Zelentsova, Alexander P Rezvykh, Iuliia O Guseva, Ana P Dorador, Mikhail B Evgen'ev, Sergei Y Funikov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alina V BespalovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Dina A KulikovaKoltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0002-9265-310X
Elena S ZelentsovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Alexander P RezvykhEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Iuliia O GusevaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Ana P DoradorHoward Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4663-4194
Mikhail B Evgen'evEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Sergei Y FunikovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-3336-6119

Funding

Russian Science Foundation 22-74-10050
6 · The paper itself

Abstract

Piwi-interacting RNAs (piRNAs) play a crucial role in silencing transposable elements (TEs) in the germ cells of Metazoa by acting as sequence-specific guides. Originating from distinct genomic loci, called piRNA clusters, piRNA can trigger an epigenetic conversion of TE insertions into piRNA clusters by means of a paramutation-like process. However, the variability in piRNA clusters' capacity to induce such conversions remains poorly understood. Here, we investigated two

Indexed as

DrosophilaGenetic LociRNA, Small InterferingAnimalsDNA Transposable ElementsDrosophila ProteinsEpigenesis, GeneticFemaleHistonesMalePiwi-Interacting RNADNA Transposable ElementsDrosophila ProteinsHistonesPiwi-Interacting RNARNA, Small InterferingDrosophila virilisgenic piRNAsmaternal effectparamutationpiRNA clusterstelomeretransposable elements

Identifiers

PMID40362480
PMCPMC12072073

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.