In Silico Insights into the Inhibition of ADAMTS-5 by Punicalagin and Ellagic Acid for the Treatment of Osteoarthritis.

Austen N Breland, Matthew K Ross, Nicholas C Fitzkee, Steven H Elder

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Molecular Dynamics Simulations with NAMD and Trajectory Analysis.Methods in molecular biology (Clifton, N.J.) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Austen N BrelandDepartment of Agricultural & Biological Engineering, Mississippi State University, Starkville, MS 39762, USA.ORCID 0009-0004-8581-6566

Matthew K RossDepartment of Comparative Biomedical Sciences, Mississippi State University, Starkville, MS 39762, USA.ORCID 0000-0002-9167-8452

Nicholas C FitzkeeDepartment of Chemistry, Mississippi State University, Starkville, MS 39762, USA.ORCID 0000-0002-8993-2140

Steven H ElderDepartment of Agricultural & Biological Engineering, Mississippi State University, Starkville, MS 39762, USA.ORCID 0000-0002-0446-2136

Funding

A novel approach to ultralong sustained delivery of punicalagin as a potential treatment for osteoarthritisR15AR083143 · NIAMS · MISSISSIPPI STATE UNIVERSITY · PI ELDER, STEVEN HOWARD · 2024 to 2024

$391k

National Institutes of Health (National Institute of Arthritis and Musculoskeletal and Skin Diseases) 1R15AR083143-01A1NIAMS NIH HHS R15 AR083143

6 · The paper itself

Abstract

ADAMTS-5 (aggrecanase-2) is a major metalloprotease involved in regulating the cartilage extracellular matrix. Due to its role in removing aggrecan in the progression of osteoarthritis (OA), ADAMTS-5 is often regarded as a potential therapeutic target for OA. Punicalagin (PCG), a polyphenolic ellagitannin found in pomegranate (

Indexed as

ADAMTS5 ProteinEllagic AcidHydrolyzable TanninsOsteoarthritisAnimalsCartilage, ArticularComputer SimulationHumansMolecular Docking SimulationSwineADAMTS5 ProteinADAMTS5 protein, humanEllagic AcidHydrolyzable Tanninspunicalaginaggrecanaseellagic acidmolecular dockingosteoarthritispunicalagin

Identifiers

PMID40362332

DOI10.3390/ijms26094093

PMCPMC12071641

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.