Evidence map›Paper›PMID 40362322›Full record

ArticleInternational journal of molecular sciences2025

Dynamic Model of Serotonin Presynapse and Its Application to Suicide Attempt in Patients with Bipolar Disorder.

Lana Radenković, Jelena Karanović, Maja Pantović-Stefanović, Dušan Lazić, Goran Brajušković, Maja Ivković, Jovan Pešović, Dušanka Savić-Pavićević

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lana RadenkovićUniversity of Belgrade-Faculty of Biology, Centre for Human Molecular Genetics, Studentski trg 16, 11000 Belgrade, Serbia.
Jelena KaranovićLaboratory for Molecular Biology, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444A, 11042 Belgrade, Serbia.ORCID 0000-0002-6291-5527
Maja Pantović-StefanovićClinic for Psychiatry, University Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia.ORCID 0000-0002-2263-0885
Dušan LazićUniversity of Belgrade-Faculty of Biology, Centre for Human Molecular Genetics, Studentski trg 16, 11000 Belgrade, Serbia.ORCID 0009-0006-0350-3246
Goran BrajuškovićUniversity of Belgrade-Faculty of Biology, Centre for Human Molecular Genetics, Studentski trg 16, 11000 Belgrade, Serbia.ORCID 0000-0002-3935-6755
Maja IvkovićClinic for Psychiatry, University Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia.ORCID 0000-0003-1976-2075
Jovan PešovićUniversity of Belgrade-Faculty of Biology, Centre for Human Molecular Genetics, Studentski trg 16, 11000 Belgrade, Serbia.
Dušanka Savić-PavićevićUniversity of Belgrade-Faculty of Biology, Centre for Human Molecular Genetics, Studentski trg 16, 11000 Belgrade, Serbia.ORCID 0000-0002-2079-4077

Funding

Ministry of Science, Technological Development and Innovation of the Republic of Serbia 451-03-65/2024-03/200178Ministry of Science, Technological Development and Innovation of the Republic of Serbia 451-03-66/2024-03/200178
6 · The paper itself

Abstract

Suicide attempts are prevalent among patients with bipolar disorder (BD). Impaired serotonin (5-HT) system in the pathogenesis of suicide attempt is partially heritable. To quantify the combined effects of multiple genetic variants, we developed a dynamic model of the 5-HT presynapse with functionally integrated individual genetic variants. The model includes five genetic variants in 5-HT system genes (

Indexed as

Bipolar DisorderSerotoninSuicide, AttemptedAdultFemaleHumansMaleMiddle AgedMonoamine OxidaseSerotonin Plasma Membrane Transport ProteinsMonoamine OxidaseSerotoninSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, humanbipolar disorderdynamic modelgenetic variantsserotonin systemsuicide attempt

Identifiers

PMID40362322
PMCPMC12072092

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.