Evidence map›Paper›PMID 40362293›Full record

ArticleInternational journal of molecular sciences2025

Identification of Potential Prophylactic Medical Countermeasures Against Acute Radiation Syndrome (ARS).

Kia T Liermann-Wooldrik, Arpita Chatterjee, Elizabeth A Kosmacek, Molly S Myers, Oluwaseun Adebisi, Louise Monga-Wells, Liu Mei, Michelle P Takacs, Patrick H Dussault, Daniel R Draney and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Kia T Liermann-WooldrikDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0009-0002-3070-2743
Arpita ChatterjeeDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Elizabeth A KosmacekDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Molly S MyersDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Oluwaseun AdebisiDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Louise Monga-WellsDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Liu MeiDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Michelle P TakacsDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Patrick H DussaultDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Daniel R DraneyDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Robert PowersDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.ORCID 0000-0001-9948-6837
James W CheccoDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.ORCID 0000-0003-1165-6163
Chittibabu GudaDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-5393-9316
Tomáš HelikarDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
David B BerkowitzDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.ORCID 0000-0001-7550-0112
Kenneth W BaylesDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Alan H EpsteinOccupational and Environmental Medicine, Defense Health Agency, Falls Church, VA 22042, USA.
Lynnette CaryDivision of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Daryl J MurryDepartment of Pharmacy Practice and Science, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-4169-5027
Rebecca E Oberley-DeeganDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-0391-142X

Funding

Software for collaborative construction, simulation, and analysis of mechanistic computational models of biological systemsR35GM119770 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI Tomas Helikar · 2016 to 2026
$4.4M
National Strategic Research Institute FA4600-18-9001NIGMS NIH HHS R35 GM119770
6 · The paper itself

Abstract

Acute radiation syndrome (ARS) occurs when hematopoietic or gastrointestinal cells are damaged by radiation exposure causing DNA damage to the bone marrow and gastrointestinal epithelial stem cell populations. In these highly proliferative cell types, DNA damage inhibits stem cell repopulation. In humans and animals, this inability to regenerate stem cells is lethal. Within this manuscript, several compounds, Amifostine, Captopril, Ciprofloxacin, PrC-210, 5-AED (5-androstene-3β,17β-diol), and 5-AET (5-androstene-3β,7β,17B-triol), are assessed for their ability to protect against ARS in an in vitro and/or in vivo setting. ARS was accomplished by irradiating mouse bone marrow cells or rat intestinal epithelial (IEC-6) cells in vitro with 4-8 Gy and in vivo by exposing

Indexed as

Acute Radiation SyndromeMedical CountermeasuresRadiation-Protective AgentsAmifostineAnimalsBone Marrow CellsCell LineCell SurvivalDNA DamageMaleMiceRatsWhole-Body IrradiationAmifostineRadiation-Protective Agentsacute radiation syndromeDNA damageradioprotection

Identifiers

PMID40362293
PMCPMC12072061

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.