Evidence map›Paper›PMID 40362273›Full record

ArticleInternational journal of molecular sciences2025

FAM20B-Catalyzed Glycosylation Regulates the Chondrogenic and Osteogenic Differentiation of the Embryonic Condyle by Controlling IHH Diffusion and Release.

Xiaoyan Chen, Han Liu, Yuhong Huang, Leilei Li, Xuxi Jiang, Bo Liu, Nan Li, Lei Zhu, Chao Liu, Jing Xiao

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Frontiers in cell and developmental biology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoyan ChenDepartment of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian 116044, China.
Han LiuDepartment of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian 116044, China.
Yuhong HuangDepartment of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian 116044, China.
Leilei LiDepartment of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian 116044, China.
Xuxi JiangDepartment of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian 116044, China.
Bo LiuInstitute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian 116044, China.
Nan LiDepartment of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian 116044, China.
Lei ZhuDepartment of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian 116044, China.
Chao LiuDepartment of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian 116044, China.ORCID 0000-0002-3584-0224
Jing XiaoDepartment of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian 116044, China.

Funding

National Natural Science Foundation of China 82270949National Natural Science Foundation of China 82370916
6 · The paper itself

Abstract

Although the roles of proteoglycans (PGs) have been well documented in the development and homeostasis of the temporomandibular joint (TMJ), how the glycosaminoglycan (GAG) chains of PGs contribute to TMJ chondrogenesis and osteogenesis still requires explication. In this study, we found that FAM20B, a hexokinase essential for attaching GAG chains to the core proteins of PGs, was robustly activated in the condylar mesenchyme during TMJ development. The inactivation of

Indexed as

Cell DifferentiationChondrogenesisHedgehog ProteinsMandibular CondyleOsteogenesisAnimalsChondrocytesGlycosylationMiceNeural CrestHedgehog Proteinsihh protein, mouseendochondral osteogenesisFAM20Bglycosaminoglycan chainproteoglycantemporomandibular joint

Identifiers

PMID40362273
PMCPMC12071210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.