Evidence map›Paper›PMID 40362246›Full record

SynthesisInternational journal of molecular sciences2025

Hydrocarbon Exposure in Myocarditis: Rare Toxic Cause or Trigger? Insights from a Biopsy-Proven Fulminant Viral Case and a Systematic Literature Review.

Andrea S Giordani, Tommaso Simone, Anna Baritussio, Cristina Vicenzetto, Federico Scognamiglio, Filippo Donato, Luca Licchelli, Luisa Cacciavillani, Chiara Fraccaro, Giuseppe Tarantini and 6 more

Abstract readSystematic ReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Andrea S GiordaniCardiology, Department of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua-Via Giustiniani 2, 35128 Padua, Italy.ORCID 0000-0002-1525-077X
Tommaso SimoneCardiology, Department of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua-Via Giustiniani 2, 35128 Padua, Italy.
Anna BaritussioCardiology, Department of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua-Via Giustiniani 2, 35128 Padua, Italy.
Cristina VicenzettoCardiology, Department of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua-Via Giustiniani 2, 35128 Padua, Italy.
Federico ScognamiglioCardiology, Department of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua-Via Giustiniani 2, 35128 Padua, Italy.ORCID 0000-0002-4610-0950
Filippo DonatoCardiology, Department of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua-Via Giustiniani 2, 35128 Padua, Italy.
Luca LicchelliCardiology, Department of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua-Via Giustiniani 2, 35128 Padua, Italy.ORCID 0000-0002-0230-0475
Luisa CacciavillaniCardiology, Department of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua-Via Giustiniani 2, 35128 Padua, Italy.
Chiara FraccaroCardiology, Department of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua-Via Giustiniani 2, 35128 Padua, Italy.ORCID 0000-0002-3972-4642
Giuseppe TarantiniCardiology, Department of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua-Via Giustiniani 2, 35128 Padua, Italy.
Fausto BraccioniRespiratory Pathophysiology Division, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-7197-9821
Stefania RizzoCardiovascular Pathology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35131 Padova, Italy.ORCID 0000-0001-5969-4412
Monica De GaspariCardiovascular Pathology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35131 Padova, Italy.
Cristina BassoCardiovascular Pathology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-0195-9753
Renzo MarcolongoCardiology, Department of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua-Via Giustiniani 2, 35128 Padua, Italy.ORCID 0000-0002-5306-1785
Alida L P CaforioCardiology, Department of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua-Via Giustiniani 2, 35128 Padua, Italy.ORCID 0000-0002-4901-5655

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxic myocarditis (TM) is rare, and no systematic evidence is available regarding its treatment or prognosis. Hydrocarbons even more rarely cause TM, and they are associated with severe extracardiac toxicity. Moreover, a pathogenic interaction between viral and toxic agents in TM has not been studied. We present the first case of biopsy-proven parvovirus B19 (B19V) viral fulminant myocarditis diagnosed after hydrocarbon exposure, along with a systematic literature review of hydrocarbon-TM cases. A systematic literature review was conducted by searching hydrocarbon-TM cases. Clinical and prognostic data were recorded. After screening of 937 records, 7 were included. All cases were male, with a median age of 24 years (IQR 23-25). Chest pain and dyspnea were the main symptoms, but arrhythmic presentation was also reported; endomyocardial biopsy (EMB) was performed in only one case. Overall, treatment was based on supportive measures, such as antiarrhythmic and/or vasoactive therapy. Our example (male, 47 years old) is the first reported fulminant biopsy-proven case diagnosed after a massive exposure to hydrocarbons, in which EMB molecular analysis unexpectedly revealed B19V with a high viral load. Hemodynamic and arrhythmic instability required percutaneous stellate ganglion blockade and temporary wearable defibrillator use. Left ventricular function spontaneously normalized at 3 months. In conclusion, we report the first fulminant B19V myocarditis case temporally associated with aromatic hydrocarbon exposure due to a coexistence of viral and toxic causes. Our case and the systematic review show that promptly performing EMB can provide a definitive diagnosis and guide treatment, especially in severe cases in which infectious agents may contribute to myocardial damage.

Indexed as

HydrocarbonsMyocarditisParvoviridae InfectionsParvovirus B19, HumanAdultBiopsyHumansMaleMiddle AgedMyocardiumYoung AdultHydrocarbonsendomyocardial biopsyfulminant myocarditishydrocarbonsmyocarditis prognosistoxic myocarditis

Identifiers

PMID40362246
PMCPMC12071235

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.