Evidence map›Paper›PMID 40362243›Full record

ArticleInternational journal of molecular sciences2025

High-Performance Liquid Chromatographic Separation of Stereoisomers of

Gábor Németi, Róbert Berkecz, Dániel Ozsvár, Zsolt Szakonyi, Wolfgang Lindner, Aleksandra Misicka, Dagmara Tymecka, Géza Tóth, Antal Péter, István Ilisz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gábor NémetiInstitute of Pharmaceutical Analysis, University of Szeged, Somogyi u. 4, H-6720 Szeged, Hungary.ORCID 0000-0001-7312-8353
Róbert BerkeczInstitute of Pharmaceutical Analysis, University of Szeged, Somogyi u. 4, H-6720 Szeged, Hungary.ORCID 0000-0002-9076-2177
Dániel OzsvárInstitute of Pharmaceutical Analysis, University of Szeged, Somogyi u. 4, H-6720 Szeged, Hungary.
Zsolt SzakonyiInstitute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.ORCID 0000-0003-2432-8409
Wolfgang LindnerDepartment of Analytical Chemistry, University of Vienna, Währinger Strasse 38, 1090 Vienna, Austria.
Aleksandra MisickaFaculty of Chemistry, University of Warsaw, Pasteura Str. 1, 02-093 Warsaw, Poland.ORCID 0000-0001-7446-2396
Dagmara TymeckaFaculty of Chemistry, University of Warsaw, Pasteura Str. 1, 02-093 Warsaw, Poland.ORCID 0000-0002-8909-4087
Géza TóthInstitute of Biochemistry, Biological Research Centre, Temesvári krt. 62, H-6725 Szeged, Hungary.
Antal PéterInstitute of Pharmaceutical Analysis, University of Szeged, Somogyi u. 4, H-6720 Szeged, Hungary.
István IliszInstitute of Pharmaceutical Analysis, University of Szeged, Somogyi u. 4, H-6720 Szeged, Hungary.ORCID 0000-0001-8282-457X

Funding

Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund TKP2021-EGA-32National Research, Development and Innovation Office K137607
6 · The paper itself

Abstract

Novel peptides based on common amino acid building blocks may serve as possible drug candidates; however, their flexible structures may require stabilization via the incorporation of conformational constraints. The insertion of unusual amino acids is a feasible option that may provide improved pharmacokinetic and pharmacodynamic properties of such peptide-type drugs. The stereochemical purity of these kinds of building blocks must be verified by an efficient separation technique, such as high-performance liquid chromatography. Here, we present and discuss the results of the stereoselective separation mechanism of

Indexed as

Amino AcidsCinchona AlkaloidsChromatography, High Pressure LiquidChromatography, Ion ExchangeStereoisomerismAmino AcidsCinchona AlkaloidsCinchona alkaloid-based chiral stationary phasesenantioselective separationhigh-performance liquid chromatography (HPLC)ß-methyl amino acids

Identifiers

PMID40362243
PMCPMC12072104

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.