Evidence map›Paper›PMID 40362226›Full record

SynthesisInternational journal of molecular sciences2025

Determining the Risk of Type 2 Diabetes for rs1801133 Genotypes in Multiethnic Populations: A Global Meta-Epidemiological Study.

Fahrul Nurkolis, Nurlinah Amalia, Yosi Yohanes Putra Tandi, Ariq Fadhil Athallah, Muhammad Reva Aditya, Ammar Nojaid, Farizky Martriano Humardani, Achmad Fabiansyah Prapriatna, Nurpudji Astuti Taslim, Dante Saksono Harbuwono and 1 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fahrul NurkolisFaculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia.ORCID 0000-0003-2151-0854
Nurlinah AmaliaMedical Research Center of Indonesia, Surabaya 60281, Indonesia.ORCID 0000-0003-1084-6301
Yosi Yohanes Putra TandiDepartment of Internal Medicine, Dr. Cipto Mangunkusumo National Central Hospital, Jakarta 10430, Indonesia.ORCID 0009-0009-1566-3900
Ariq Fadhil AthallahMedical Study Program, Faculty of Medicine, Universitas Brawijaya, Malang 65145, Indonesia.
Muhammad Reva AdityaMedical Study Program, Faculty of Medicine, Universitas Brawijaya, Malang 65145, Indonesia.ORCID 0009-0005-4799-385X
Ammar NojaidMedical Study Program, Faculty of Medicine, Universitas Brawijaya, Malang 65145, Indonesia.ORCID 0000-0003-2895-2735
Farizky Martriano HumardaniDoctoral Program in Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang 65145, Indonesia.
Achmad Fabiansyah PrapriatnaMedical Study Program, Faculty of Medicine, Universitas Brawijaya, Malang 65145, Indonesia.
Nurpudji Astuti TaslimDivision of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia.ORCID 0000-0003-1349-5367
Dante Saksono HarbuwonoDivision of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta 10430, Indonesia.
Raymond Rubianto TjandrawinataCenter for Pharmaceutical and Nutraceutical Research and Policy, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta 12930, Indonesia.ORCID 0000-0003-0461-9874

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rs1801133 (C677T) polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene has been linked to type 2 diabetes (T2D) risk. This study aimed to assess the association between rs1801133 genotypes (CC, CT, TT) and T2D across multiethnic populations and to identify genotype- and region-specific risks. A global meta-epidemiological analysis was conducted using data from 19 studies comprising 6479 participants from Asia, Africa, Europe, and America. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated using random-effects models. Subgroup analyses by region were also performed. The results of the CC vs. CT dominant genetic model were OR 95% CI = 0.63 (0.46-0.87);

Indexed as

Diabetes Mellitus, Type 2EthnicityGenetic Predisposition to DiseaseMethylenetetrahydrofolate Reductase (NADPH2)Polymorphism, Single NucleotideGenotypeHumansRisk FactorsMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanCC genotypemetabolic syndromemethylenetetrahydrofolate reductasemultiethnic grouprs1801133type 2 diabetes

Identifiers

PMID40362226
PMCPMC12071517

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.