Evidence map›Paper›PMID 40362198›Full record

ArticleInternational journal of molecular sciences2025

Antioxidant and Neuroprotective Properties of Selected Pyrrole-Containing Azomethine Compounds in Neurotoxicity Models In Vitro.

Denitsa Stefanova, Alime Garip, Emilio Mateev, Magdalena Kondeva-Burdina, Yordan Yordanov, Diana Tzankova, Alexandrina Mateeva, Iva Valkova, Maya Georgieva, Alexander Zlatkov and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. UnveilingInternational journal of molecular sciences · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Denitsa StefanovaDepartment Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University-Sofia, 1431 Sofia, Bulgaria.ORCID 0000-0002-6859-9369
Alime GaripDepartment Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University-Sofia, 1431 Sofia, Bulgaria.
Emilio MateevDepartment "Pharmaceutical Chemistry", Faculty of Pharmacy, Medical University-Sofia, 1431 Sofia, Bulgaria.ORCID 0000-0002-5885-7213
Magdalena Kondeva-BurdinaDepartment Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University-Sofia, 1431 Sofia, Bulgaria.
Yordan YordanovDepartment Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University-Sofia, 1431 Sofia, Bulgaria.ORCID 0000-0003-1029-9870
Diana TzankovaDepartment "Pharmaceutical Chemistry", Faculty of Pharmacy, Medical University-Sofia, 1431 Sofia, Bulgaria.ORCID 0000-0002-1708-1287
Alexandrina MateevaDepartment "Pharmaceutical Chemistry", Faculty of Pharmacy, Medical University-Sofia, 1431 Sofia, Bulgaria.ORCID 0000-0003-1905-7130
Iva ValkovaDepartment "Chemistry", Faculty of Pharmacy, Medical University-Sofia, 1431 Sofia, Bulgaria.
Maya GeorgievaDepartment "Pharmaceutical Chemistry", Faculty of Pharmacy, Medical University-Sofia, 1431 Sofia, Bulgaria.ORCID 0000-0002-4752-5002
Alexander ZlatkovDepartment "Pharmaceutical Chemistry", Faculty of Pharmacy, Medical University-Sofia, 1431 Sofia, Bulgaria.ORCID 0000-0002-1695-8454
Virginia TzankovaDepartment Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University-Sofia, 1431 Sofia, Bulgaria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases involve oxidative stress and enzyme dysregulation, necessitating novel neuroprotective agents. This study evaluates the neuroprotective and antioxidant potential of seven pyrrole-based compounds with predicted radical scavenging activity and inhibitory effects on monoamine oxidase B (MAO-B) and acetylcholinesterase (AChE). The compounds were tested in vitro using SH-SY5Y neuroblastoma cells and subcellular rat brain fractions, including synaptosomes, mitochondria, and microsomes. Neuroprotective and antioxidant effects were assessed in oxidative stress models, including H

Indexed as

AntioxidantsNeuroprotective AgentsPyrrolesThiosemicarbazonesAcetylcholinesteraseAnimalsCell Line, TumorHumansLipid PeroxidationMitochondriaMonoamine OxidaseOxidative StressRatsSynaptosomesAcetylcholinesteraseAntioxidantsMonoamine OxidaseNeuroprotective AgentsPyrrolesThiosemicarbazonesADMEbrain subcellular fractionsin silicoin vitro neuroprotectionpyrrole-based compoundsSH-SY5Y

Identifiers

PMID40362198
PMCPMC12072147

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.