Evidence map›Paper›PMID 40362190›Full record

ReviewInternational journal of molecular sciences2025

Plant-Derived Lapachol Analogs as Selective Metalloprotease Inhibitors Against

Paulo A Melo, Pâmella Dourila Nogueira-Souza, Mayara Amorim Romanelli, Marcelo A Strauch, Marcelo de Oliveira Cesar, Marcos Monteiro-Machado, Fernando Chagas Patrão-Neto, Sabrina R Gonsalez, Nilton Ghiotti Siqueira, Edgar Schaeffer and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Paulo A MeloLaboratório de Farmacologia das Toxinas, Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.
Pâmella Dourila Nogueira-SouzaLaboratório de Farmacologia das Toxinas, Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.
Mayara Amorim RomanelliLaboratório de Farmacologia das Toxinas, Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.
Marcelo A StrauchDepartamento de Ciências Fisiológicas, Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica 23890-000, Brazil.ORCID 0000-0002-9576-6310
Marcelo de Oliveira CesarLaboratório de Farmacologia das Toxinas, Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.
Marcos Monteiro-MachadoLaboratório de Farmacologia das Toxinas, Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.ORCID 0000-0002-1657-1356
Fernando Chagas Patrão-NetoLaboratório de Farmacologia das Toxinas, Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.
Sabrina R GonsalezFaculdade de Medicina, Universidade Federal do Rio de Janeiro, Campus Macaé, Rio de Janeiro 21941-901, Brazil.
Nilton Ghiotti SiqueiraCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Rio Branco 69920-900, Brazil.ORCID 0000-0002-8824-5701
Edgar SchaefferInstituto de Pesquisas de Produtos Naturais Walter Mors, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.
Paulo R R CostaInstituto de Pesquisas de Produtos Naturais Walter Mors, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.
Alcides J M da SilvaInstituto de Pesquisas de Produtos Naturais Walter Mors, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.ORCID 0000-0002-3200-0318

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant compounds that inhibit snake venom activities are relevant and can provide active molecules to counteract snake venom effects. Numerous studies on snake viperid venoms found that metalloproteinases play a significant role in the pathophysiology of hemorrhage that occurs on envenomation. Preclinical studies using vitro and in vivo protocols investigated natural compounds and viperid snake venoms, evaluating the enzymatic, procoagulant, hemorrhagic, edematogenic, myotoxic, and lethal activities. Many studies focused on

Indexed as

BothropsCrotalid VenomsMetalloproteasesNaphthoquinonesPlant ExtractsProtease InhibitorsAnimalsHemorrhageHumansCrotalid VenomsMetalloproteasesNaphthoquinonesPlant ExtractsProtease InhibitorsBothrops atroxlapachol analogsmetalloproteinasesplant compoundssnake venomsynthetic inhibitorstissue hemorrhage

Identifiers

PMID40362190
PMCPMC12071312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.