Evidence map›Paper›PMID 40362085›Full record

ArticleAnimals : an open access journal from MDPI2025

Repairing Qinling Giant Panda Skin Wounds Using Adipose Mesenchymal Stem Cell-Derived Extracellular Vesicles.

Suhua Gong, Hongyu Niu, Yanni Jia, Mengjie Liu, Xiaoyu Ren, Danhui Zhang, Jiena Shen, Chuangxue Yang, Yinghu Lei, Pengpeng Zhao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Suhua GongCollege of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.
Hongyu NiuCollege of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.
Yanni JiaCollege of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.
Mengjie LiuCollege of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.
Xiaoyu RenCollege of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.
Danhui ZhangResearch Center for the Qinling Giant Panda, Rescue Base of Rare Wild Animals in Shaanxi Province, Louguantai, Xi'an 710402, China.
Jiena ShenResearch Center for the Qinling Giant Panda, Rescue Base of Rare Wild Animals in Shaanxi Province, Louguantai, Xi'an 710402, China.
Chuangxue YangLouguantai State Owned Ecological Experimental Forest Farm in Shaanxi Province, Zhouzhi, Xi'an 710402, China.
Yinghu LeiResearch Center for the Qinling Giant Panda, Rescue Base of Rare Wild Animals in Shaanxi Province, Louguantai, Xi'an 710402, China.
Pengpeng ZhaoResearch Center for the Qinling Giant Panda, Rescue Base of Rare Wild Animals in Shaanxi Province, Louguantai, Xi'an 710402, China.
Pengfei LinCollege of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.ORCID 0000-0001-6815-4418

Funding

Shaanxi Academy of Forestry Science and Technology Innovation Special Project SXLk2020-0303Shaanxi Forestry Science and Technology Innovation Key Special Project SXLK2023-02-22The Key Research and Development Program of Shaanxi 2023-YBNY-135
6 · The paper itself

Abstract

The Qinling giant panda has a high susceptibility to skin damage, which affects its survival. Although their healing efficacy in panda injuries remains unexplored, extracellular vesicles from adipose-derived mesenchymal stem cells (ADMSC-EVs) have shown promise in regenerative medicine. In this study, ADMSC-EVs were successfully obtained from Qinling giant pandas using ultracentrifugation, and proteomic techniques were used to analyze their composition and function. Primary skin fibroblasts from Qinling giant pandas were isolated and cultured to explore the effects of ADMSC-EVs on cell proliferation and migration. Additionally, a mouse model of skin injury was used to assess their wound healing effects. The ADMSC-EVs contained various substances, particularly proteins, with fifty unique proteins involved in transport, catabolism, and signal transduction identified. The application of ADMSC-EVs in a mouse model accelerated wound healing and promoted the regeneration of the epidermal and dermal layers. It facilitated the repair of skin appendages, including hair follicles and sebaceous glands. Additionally, ADMSC-EVs enhanced collagen deposition, stimulated angiogenesis, and reduced inflammation. Our findings confirm that ADMSC-EVs significantly improve skin healing, thus supporting the theoretical framework for the clinical use of giant panda extracellular vesicles and underscoring their potential for preserving the genetic resources of the Qinling giant panda.

Indexed as

adipose mesenchymal stem cellsextracellular vesiclesproteomicsQinling giant pandaskin wound repair

Identifiers

PMID40362085
PMCPMC12070915

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.