Evidence map›Paper›PMID 40361906›Full record

ReviewDiagnostics (Basel, Switzerland)2025

The Global Burden of Obstructive Sleep Apnea.

Giannicola Iannella, Annalisa Pace, Mario Giuseppe Bellizzi, Giuseppe Magliulo, Antonio Greco, Armando De Virgilio, Enrica Croce, Federico Maria Gioacchini, Massimo Re, Andrea Costantino and 9 more

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 70 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07465874 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Validity and Reliability of the 6-Minute Pegboard and Ring Test (6PBRT) in Adults With Obstructive Sleep Apnea: A Polysomnography-Based Methodological Study

TypeobservationalSponsorMardin Artuklu UniversityRan2026 to 2026Enrolled80ConditionsObstructive Sleep Apnea, Sleep Apnea
NCT07539870 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Isolated and Combined Effects of Orofacial Myofunctional Therapy and Continuous Positive Airway Pressure on the Apnea-Hypopnea Index and Mandibular Excursion in Adults With Mild-to-Moderate Obstructive Sleep Apnea: The OMPACT-OSA Randomized Controlled Trial

TypeinterventionalSponsorSaint-Joseph UniversityRan2026 to 2028Enrolled168ConditionsObstructive Sleep ApneaArmsSham Breathing Sessions, Orofacial Myofunctional Therapy, Continuous Positive Airway Pressure, Standard of Care Sleep-Hygiene and Lifestyle Counseling
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  19. Performance of nine large language models on real-world polysomnography interpretation for obstructive sleep apnea: a multi-dimensional comparative analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Giannicola IannellaOrgani di Senso Department, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-1781-2809
Annalisa PaceOrgani di Senso Department, Sapienza University of Rome, 00161 Rome, Italy.
Mario Giuseppe BellizziOrgani di Senso Department, Sapienza University of Rome, 00161 Rome, Italy.
Giuseppe MagliuloOrgani di Senso Department, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-3052-1969
Antonio GrecoOrgani di Senso Department, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-4824-9871
Armando De VirgilioOrgani di Senso Department, Sapienza University of Rome, 00161 Rome, Italy.
Enrica CroceOrgani di Senso Department, Sapienza University of Rome, 00161 Rome, Italy.
Federico Maria GioacchiniEar, Nose and Throat Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Via Conca 71, 60020 Ancona, Italy.
Massimo ReEar, Nose and Throat Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Via Conca 71, 60020 Ancona, Italy.
Andrea CostantinoDepartment of Otolaryngology-Head and Neck Surgery, AdventHealth Orlando, Orlando, FL 32789, USA.
Manuele CasaleIntegrated Therapies in Otolaryngology, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.
Antonio MoffaIntegrated Therapies in Otolaryngology, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.
Jerome R LechienDivision of Laryngology and Broncho-Esophagology, Department of Otolaryngology-Head Neck Surgery, EpiCURA Hospital, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), 7000 Mons, Belgium.ORCID 0000-0002-0845-0845
Salvatore CocuzzaDepartment of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia" ENT Section, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-6135-0958
Claudio ViciniDepartment ENT & Audiology, University of Ferrara, 44121 Ferrara, Italy.
Alberto CarantiDepartment ENT & Audiology, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-0698-937X
Rosario Marchese AragonaOtolaryngology Section, Department of Neuroscience, University of Padova, 35100 Padova, Italy.
Mario LentiniDepartment of Medicine and Surgery, University of Enna Kore, 94100 Enna, Italy.ORCID 0009-0004-8127-5045
Antonino ManiaciDepartment of Medicine and Surgery, University of Enna Kore, 94100 Enna, Italy.ORCID 0000-0002-1251-0185

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study reviewed the global prevalence, health and socioeconomic impact, and management approaches of obstructive sleep apnea. The narrative review examined three key dimensions: (1) worldwide OSA prevalence across different regions, accounting for variations in diagnostic standards; (2) OSA's effects on health outcomes and socioeconomic conditions across diverse populations and healthcare systems; and (3) current global approaches to OSA diagnosis, treatment, and public health management. Despite advances in diagnosis and treatment, a large proportion of OSA cases remain undiagnosed or inadequately managed. The findings show that untreated OSA significantly increases public safety risks, particularly regarding motor vehicle and occupational accidents, while also creating a substantial pool of patients at high risk for systemic complications with severe impacts on overall health. There is a critical need for increased public awareness, universal screening approaches, and integrated care strategies to address this global health challenge and reduce its considerable socioeconomic burden. Our review uniquely addresses global disparities in OSA prevalence, clarifies the health and socioeconomic impacts that remain underexplored in the current literature, and suggests concrete strategies for public health and clinical management improvement worldwide.

Indexed as

epidemiologyglobal burdenobstructive sleep apneaOSAsleep

Identifiers

PMID40361906
PMCPMC12071658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.