Evidence map›Paper›PMID 40361685›Full record

ArticleFoods (Basel, Switzerland)2025

Development of NADES-Annatto Seed Extract for Enhancing 3D Printed Food Designed for Dysphagia Patients.

Sara Kierulff Balabram, Larissa Tessaro, Maria Eduarda de Almeida Astolfo, Pedro Augusto Invernizzi Sponchiado, Stanislau Bogusz Junior, Bianca C Maniglia

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sara Kierulff BalabramSão Carlos Institute of Chemistry, University of Sao Paulo, Av Trabalhador São Carlense, 400, São Carlos 13566-590, SP, Brazil.ORCID 0009-0009-1210-2526
Larissa TessaroSão Carlos Institute of Chemistry, University of Sao Paulo, Av Trabalhador São Carlense, 400, São Carlos 13566-590, SP, Brazil.ORCID 0000-0002-1670-9802
Maria Eduarda de Almeida AstolfoSão Carlos Institute of Chemistry, University of Sao Paulo, Av Trabalhador São Carlense, 400, São Carlos 13566-590, SP, Brazil.ORCID 0009-0005-3806-272X
Pedro Augusto Invernizzi SponchiadoSão Carlos Institute of Chemistry, University of Sao Paulo, Av Trabalhador São Carlense, 400, São Carlos 13566-590, SP, Brazil.
Stanislau Bogusz JuniorSão Carlos Institute of Chemistry, University of Sao Paulo, Av Trabalhador São Carlense, 400, São Carlos 13566-590, SP, Brazil.ORCID 0000-0002-4382-5745
Bianca C ManigliaSão Carlos Institute of Chemistry, University of Sao Paulo, Av Trabalhador São Carlense, 400, São Carlos 13566-590, SP, Brazil.ORCID 0000-0003-4174-5474

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior finance code 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/080727-0, 2024/08072-3 and 2022/03229-8 (project financing), 2024/10994-8 (Postdoctoral fel-lowship of L.T.), 2023/17512-6 (Ph.D. scholarship of P.S.), 2024/20808-0 (Master scholarship of M.A.), and 2024/04586-4 (Undergraduate research scholarship ofNational Council for Scientific and Technological Development grant number 153726/2024-5 (Postdoctoral fellowship of L.T.),
6 · The paper itself

Abstract

This study develops a 3D printed food designed for dysphagia patients, incorporating a natural deep eutectic solvent (NADES)-annatto seed extract. The objective was to enhance textural properties and bioactive retention in food matrices tailored for individuals with swallowing difficulties. NADES extraction was compared to ethanol, with the extracts incorporated into gelatin and starch hydrogels. Gelatin, a widely used biopolymer, improved mechanical properties and printability, ensuring a cohesive and structured matrix for 3D printing. Textural analysis showed that starch-based 3D printed hydrogels exhibited lower hardness, adhesiveness, and gumminess compared to molded samples, making them more suitable for dysphagia-friendly diets than gelatin-based formulations. The IDDSI fork test confirmed that selected 3D printed samples met essential texture requirements for safe consumption by dysphagia patients. The combination of NADES-extracted bioactive compounds and 3D printing enabled the development of functional foods with optimized texture and nutritional properties. Additionally, gelatin played a key role in enhancing elasticity and structural integrity in printed samples, reinforcing its potential for food texture modification. This study presents an innovative approach to dysphagia-friendly food formulation, integrating green extraction methods with advanced food processing technologies, paving the way for safer, nutritionally enhanced, and customizable functional foods for individuals with swallowing disorders.

Indexed as

3D food printingannatto seed extractbioactive compoundsdysphagia-friendly foodsfood rheologyfunctional food designhydrogel-based foodIDDSI frameworknatural deep eutectic solvent (NADES)texture profile analysis (TPA)

Identifiers

PMID40361685
PMCPMC12072093

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.