Development of an Integrated Multifunctional Column for Rapid Pretreatment and Determination of Trichothecenes in Cereals and Feeds with HPLC-MS/MS.

Sisi Liu, Yu Wu, Tongtong Liu, Jin Ye, Li Li, Xiao Guan, Songxue Wang

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sisi LiuSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Yu WuNFSRA Key Laboratory of Grain and Oil Quality and Safety, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China.

Tongtong LiuNFSRA Key Laboratory of Grain and Oil Quality and Safety, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China.

Jin YeNFSRA Key Laboratory of Grain and Oil Quality and Safety, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China.ORCID 0000-0001-9619-4943

Li LiNFSRA Key Laboratory of Grain and Oil Quality and Safety, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China.

Xiao GuanSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Songxue WangNFSRA Key Laboratory of Grain and Oil Quality and Safety, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China.ORCID 0000-0002-0555-5545

Funding

Foreign high end Talents Introduction Plan 110000366320238000Fundamental Research Funds for the Central Research Institutes ZX2426Talent Project of National Food and Strategic Reserves Administration QN2022202, LJ2022201the National Key R&D Program of China 2022YFE0137500

6 · The paper itself

Abstract

The frequent detection of trichothecenes in grains highlights critical health risks to humans and animals. Based on the hybrid sorbent strategies, this study developed an innovative multifunctional column (ASAG563) integrating extraction, purification, and filtration to address limitations of existing methods, including cumbersome process, protracted duration, harmful to the environment, and significant matrix interference. Coupled with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), the ASAG563 column demonstrated superior recoveries (80.8-117.8%) and quantification limits (2.02~48.41 µg/kg) across cereals and feeds, with low relative standard deviations (<6.8%). Compared to commercial MFCs, the ASAG563 column simplified the process, reduced material consumption, saved 50% of analysis time, and effectively eliminated matrix effects. Analysis of 512 maize for feedstuff samples from Northeast China revealed significant contaminations with deoxynivalenol (DON) and its derivatives, emphasizing the necessity for enhanced regulatory measures. This novel integrated multifunctional pretreatment column presents a convenient, cost-effective, and eco-friendly solution for accurate TCT detection, significantly advancing analytical capabilities.

Indexed as

cerealsfeedsHPLC-MS/MSmultifunctional columnmycotoxinstrichothecenes

Identifiers

PMID40361548

DOI10.3390/foods14091466

PMCPMC12071380

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.