Evidence map›Paper›PMID 40361470›Full record

ArticleCancers2025

Molecular Profiling of Nasopharyngeal Carcinoma Using the AACR Project GENIE Repository.

Beau Hsia, Asritha Sure, Roshan Dongre, Nicolas Jo, Julia Kuzniar, Gabriel Bitar, Saif A Alshaka, Jeeho D Kim, Bastien A Valencia-Sanchez, Michael G Brandel and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Beau HsiaSchool of Medicine, Creighton University, Phoenix, AZ 85012, USA.ORCID 0009-0009-6403-502X
Asritha SureSchool of Medicine, Boston University, Boston, MA 02118, USA.ORCID 0009-0009-2582-9855
Roshan DongreSchool of Engineering Medicine, Texas A&M University, Houston, TX 77030, USA.ORCID 0009-0005-8589-086X
Nicolas JoHerbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.
Julia KuzniarRutgers New Jersey Medical School, Newark, NJ 07103, USA.
Gabriel BitarSchool of Medicine, Creighton University, Phoenix, AZ 85012, USA.
Saif A AlshakaSchool of Medicine, Creighton University, Phoenix, AZ 85012, USA.ORCID 0000-0002-9509-151X
Jeeho D KimDepartment of Otolaryngology-Head and Neck Surgery, Naval Medical Center San Diego, San Diego, CA 92134, USA.ORCID 0000-0002-6691-3174
Bastien A Valencia-SanchezDepartment of Otolaryngology-Head and Neck Surgery, Mayo Clinic Florida, Jacksonville, FL 32224, USA.ORCID 0000-0002-1957-7892
Michael G BrandelDepartment of Neurosurgery, University of California San Diego-Rady Children's Hospital, San Diego, CA 92123, USA.ORCID 0000-0001-7422-390X
Mariko SatoDepartment of Pediatric Oncology, Children's Hospital of Orange County, Orange, CA 92868, USA.ORCID 0000-0002-4748-4634
John Ross CrawfordDepartment of Pediatrics and Neurology, Children's Hospital Orange County, University of California Irvine, Orange, CA 92868, USA.
Michael L LevyDepartment of Neurosurgery, University of California San Diego-Rady Children's Hospital, San Diego, CA 92123, USA.
Sean P PolsterDepartment of Neurosurgery, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-3229-5021
Vijay A PatelDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-8145-1721

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNasopharyngeal carcinoma (NPC) is a rare head and neck cancer arising from the mucosal lining of the nasopharynx, for which systemic therapeutic options remain scarce, reflecting the limited characterization of its genomic profile. This study utilized a large patient-level genomic repository to characterize genetic alterations, identify potential therapeutic targets, and improve disease modeling in NPC.

methodsA retrospective analysis of NPC samples was conducted using the AACR Project GENIE database. Targeted sequencing data were analyzed for recurrent somatic mutations, tumor mutational burden, and chromosomal copy number variations, with significance set at

resultsFrequent mutations were identified in

conclusionsThis study presents a detailed genomic profile of NPC, identifying key mutations within established cancer-associated pathways. The identification of frequently mutated pathways (p53, NF-κB, and PI3K) suggests potential targets for novel therapies. Furthermore, distinct mutational landscapes in female and Asian NPC patients offer possibilities for precision therapeutic interventions.

Indexed as

AACR project GENIEbiomarker discoverycancer genomicsCYLDKMT2Dnasopharyngeal carcinomasNF-κBp53PI3Ksomatic mutationstargeted therapyTP53

Identifiers

PMID40361470
PMCPMC12071154

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.