ArticleCancers2025
A Comparison of Surgical and Functional Outcomes in Prostate Cancer Patients with Overweight and Obesity Participating in a Presurgical Weight Loss Trial.
Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01886677 (Exploring the Impact of Negative Energy Balance in Men With Prostate Cancer), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exploring the Impact of Negative Energy Balance in Men With Prostate Cancer
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of preoperative weight-loss interventions on outcomes after elective non-bariatric surgery: meta-analysis.BJS open · 2025Pooled it
- Preoperative physical exercise training for people scheduled for major abdominal surgery.The Cochrane database of systematic reviews · 2026Article
- Robot-assisted radical prostatectomy in morbidly obese men: why functional outcomes, weight-loss interventions, and anesthetic risks must complement perioperative and oncologic analysis.Journal of robotic surgery · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
BACKGROUND/
objectivesObesity and abdominal adiposity are associated with worse surgical and functional outcomes in prostate cancer (PCa) patients. This exploratory study assessed whether reductions in total body fat mass (TFM) among overweight and obese PCa patients enrolled in a diet and exercise weight loss intervention prior to robotic-assisted radical prostatectomy (RARP) improved outcomes.
methodsIn this secondary analysis of an NIH-funded randomized controlled trial (NCT01886677) conducted 2012-2015, twenty-nine patients with newly diagnosed, pathology-confirmed PCa who participated and underwent RARP were evaluated for percent change in TFM and divided into High Fat Losers who lost ≥1% TFM per week and Low Fat Losers who lost <1% TFM per week. High versus Low Fat Losers were compared on operative time (OT), estimated blood loss (EBL), length of hospital stay (LOS), incidence of surgical or postoperative complications, and incontinence and impotence scores at first postoperative follow-up.
resultsThere was a statistically significant difference between High versus Low Fat Losers with respect to overall complications ( CONCLUSIONS AND RELEVANCE: Findings implicate the potential benefit of healthy weight loss as an adjunct to surgery, and support the need for larger trials to elucidate a clearer relationship between improvements in body composition and effects on specific surgical complications and functional outcomes.
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Registered trials
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