ArticleCancers2025
Elastography Enhances the Diagnostic Performance of Conventional Ultrasonography in Differentiating Benign from Malignant Superficial Lymphadenopathies.
Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Elastography for distinguishing lymphoma from benign and metastatic lymphadenopathy: a systematic review and Bayesian meta-analysis.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Pooled it
- Diagnostic performance and clinical utility of shear-wave elastography in musculoskeletal soft-tissue tumors: a systematic review.Frontiers in oncology · 2026Pooled it
- Can Ultrasound Elastography Be Used as an Objective Measure in Tonsillectomy Indications?Journal of clinical medicine · 2026Article
- Hematolymphoid neoplasms involving the breast: A single institution clinicopathologic study of 59 patients.Annals of hematology · 2026Article
- Can GPT-5.0 Interpret Thyroid Ultrasound Images? A Comparative TI-RADS Analysis with an Expert Radiologist.Diagnostics (Basel, Switzerland) · 2026Article
- Non-Hodgkin's lymphoma classification using 3D radiomics machine learning models for precision imaging in oncology.BMC medical imaging · 2025Article
- Multiparametric Ultrasound in the Differential Diagnosis of Soft Tissue Tumors: A Comprehensive Review.Biomedicines · 2025Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesLymph node (LN) evaluation is critical in diagnosing, staging, and managing various diseases, particularly lymphoma and metastatic cancer. Although conventional ultrasound (US) is widely used for this purpose, its limitations in reliably differentiating between benign and malignant LNs persist. Ultrasound elastography (US-E), which evaluates tissue stiffness, has emerged as a promising adjunct to improve diagnostic accuracy. This study aims to evaluate the diagnostic performance of conventional US, power Doppler US, and strain elastography (SE) in distinguishing malignant from benign superficial lymph nodes.
methodsIn this prospective study, 214 consecutive patients referred for US of enlarged LNs were enrolled. Conventional B-mode US, power Doppler, and SE were performed, and the strain ratio (SR) was calculated as a measure of LN stiffness. Histopathological examination was used as the reference standard. Diagnostic accuracy was assessed using receiver operating characteristic (ROC) analysis, and multivariable logistic regression models were applied to determine the independent predictive role of SR.
resultsAmong the 214 LNs (one for each patient), 74 (34.6%) were benign and 140 (65.4%) were malignant. The SR showed a significant association with malignancy (
conclusionsUS-E, particularly SR, is a valuable tool in the differentiation of benign and malignant superficial LNs. SR provides significant diagnostic value, especially in hematological neoplasms like Hodgkin lymphoma, and can serve as an independent predictor of malignancy. This technique, when used in combination with conventional US features, offers enhanced diagnostic performance for LN evaluation.
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