ArticleVirology journal2025
Clinical features and risk factors for Epstein-Barr virus-associated encephalitis: a retrospective cohort study.
Article in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Review
- Diagnostic criteria for Epstein-barr virus-associated encephalitis: a comment on Liu et al.Virology journal · 2025Article
- Article
- Clinical characteristics and prognostic analysis of patients with herpesvirus meningitis/encephalitis based on cerebrospinal fluid mNGS positivity.Frontiers in neurologyArticle
- Intracranial hypertension due to Epstein-Barr virus encephalitis during the postpartum period.Colombia medica (Cali, Colombia)Article
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7 authors.
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Abstract
backgroundEpstein-Barr virus (EBV) has been gradually recognized as an important pathogen of encephalitis, but our knowledge of EBV-associated encephalitis is still limited. The aim of this study was to describe the clinical features and explore the risk factors for EBV-associated encephalitis in a large cohort of Chinese patients.
methodsAll patients with confirmed encephalitis in our center from June 2020 to April 2021 were enrolled. Data were extracted from the electronic medical record system and analyzed by Student's t test, Mann-Whitney U test, chi-square test, and logistic regression analyses.
resultsThis study included a total of 364 patients diagnosed with encephalitis, among which 86 cases (23.6%) had EBV detected in their cerebrospinal fluid (CSF), and 39 cases were diagnosed with EBV-associated encephalitis. The clinical characteristics of EBV-associated encephalitis differ from those caused by other herpes viruses. Compared to other herpes virus-related encephalitis, patients with EBV encephalitis exhibited significantly higher protein levels (1.310 [0.695, 1.840] vs. 0.710 [0.490, 1.700], p < 0.001), lower glucose levels (3.030 [2.585, 3.640] vs. 3.380 [2.990, 4.030], p < 0.001), and a higher incidence of meningeal involvement on MRI (11 (30.6%) vs. 3 (6.5%), p = 0.010). Additionally, univariate logistic regression analysis revealed that age (OR = 1.015, 95% CI: 1.002-1.029), HIV infection (OR = 4.285, 95% CI: 1.582-11.816), non-tumor immunosuppression (OR = 5.713, 95% CI: 1.588-22.883), and peripheral blood EBV infection (OR = 10.204, 95% CI: 4.231-26.346) were independent risk factors for CNS EBV infection.
conclusionCompared to other herpes virus-associated encephalitis, EBV encephalitis is characterized by a higher degree of meningeal involvement, elevated CSF protein levels, lower glucose levels, and a reduced T-lymphocyte count in peripheral blood. These characteristics suggest that EBV encephalitis may have a distinct pathophysiology.
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