Evidence map›Paper›PMID 40361208›Full record

ReviewParticle and fibre toxicology2025

Investigating the impact of the dispersion protocol on the physico-chemical identity and toxicity of nanomaterials: a review of the literature with focus on TiO

Andrew McCormack, Vicki Stone, James McQuat, Helinor Johnston

Abstract readReview
In one paragraph

Review in Particle and fibre toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew McCormackInstitute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK. am349@hw.ac.uk.
Vicki StoneInstitute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK.
James McQuatPublishing Consultant, Winchester, UK.
Helinor JohnstonInstitute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Particles often require dispersion in aqueous media to allow assessment of their hazard profile. The approach used to disperse particles is not consistent in the published literature, with approaches including stirring, vortexing, shaking or sonication, and the use of biological or chemical stabilisers. Such variations in the dispersion protocol can influence the physico-chemical (PC) identity and toxicity of particles. To better understand the protocol variations and their impacts on human health, this work identified and critically reviewed publications with a specific focus on titanium dioxide (TiO

Indexed as

NanostructuresTitaniumAnimalsHumansParticle SizeSonicationToxicity TestsTitaniumtitanium dioxideAgglomerationCytotoxicityDispersant mediaDispersion protocolNanomaterialNanoparticleReactive oxygen speciesSonicationTitanium dioxide

Identifiers

PMID40361208
PMCPMC12070512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.