Evidence map›Paper›PMID 40361181›Full record

ArticleStem cell research & therapy2025

Human dental pulp stem cells attenuate airway inflammation in mice with PM

Jianling Liu, Yuehua Chen, Zhongpeng Li, Zhangwen Li, Fengjuan Lyu, Fang Wang, Aili Wang, Zhangquan Liu, Xiaoyang Liao, Jian Wu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jianling Liu *Second Department of Elderly Respiratory, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, 510080, China.
Yuehua Chen *Second Department of Elderly Respiratory, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, 510080, China.
Zhongpeng LiCritical Care Medicine Department, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Zhangwen LiSecond Department of Elderly Respiratory, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, 510080, China.
Fengjuan LyuJoint Center for Regenerative Medicine Research of South China University of Technology and the University of Western Australia, School of Medicine, South China University of Technology, Guangzhou, 515000, P.R. China.
Fang WangSecond Department of Elderly Respiratory, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, 510080, China.
Aili WangSecond Department of Elderly Respiratory, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, 510080, China.
Zhangquan LiuSecond Department of Elderly Respiratory, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, 510080, China.
Xiaoyang LiaoSecond Department of Elderly Respiratory, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, 510080, China.
Jian WuSecond Department of Elderly Respiratory, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, 510080, China. sywujian@scut.edu.cn.

Funding

Department of Finance of Guangdong Province KS0120220270Innovative Research Group Project of the National Natural Science Foundation of China 81970012Natural Science Foundation of Guangdong Province 2023A1515011587
6 · The paper itself

Abstract

backgroundFine particulate matter (PM

methodsIn a PM

resultsThe administration of hDPSCs ameliorated airway inflammation. Moreover, hDPSCs further alleviated Th2 inflammation and decreased serum IgE concentrations, along with a decrease in eosinophils in BALF. At the same time, interleukin-1β (IL-1β) and IL-18 levels in BALF and caspase-1 activity in lung tissues were reduced. In addition, immunohistochemistry showed that the expression levels of NLRP3, caspase-1, GSDMD, cleaved capsase-1 and IL-1β were reduced. The western blot results also showed that the expression level of NLRP3/caspase-1/GSDMD/cleaved capsase-1 in the classical pathway of pyroptosis decreased after hDPSCs intervention.

conclusionsThese findings provided the first evidence that hDPSCs transplantation attenuated allergic airway inflammation and mucus secretion in mice with PM

Indexed as

AsthmaDental PulpParticulate MatterPyroptosisAnimalsCaspase 1Disease Models, AnimalFemaleHumansInflammationMaleMiceMice, Inbred BALB CNLR Family, Pyrin Domain-Containing 3 ProteinCaspase 1NLR Family, Pyrin Domain-Containing 3 ProteinParticulate MatterAirway inflammationCell therapyHuman dental pulp stem cellsPM2.5-induced asthma exacerbationPyroptosis

Identifiers

PMID40361181
PMCPMC12076901

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