ArticleAntimicrobial resistance and infection control2025
Infection control interventions against carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae in an Iranian referral university hospital: A quasi-experimental study.
Article in Antimicrobial resistance and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Successful control of double carbapenemase-producingInfection prevention in practice · 2026Article
- Dynamics of clinicalApplied and environmental microbiology · 2026Article
- Prevalence of extended-spectrum β-lactamase and carbapenemase-producing Klebsiella pneumoniae in humans, animals and the environment in Northwest Amhara, Ethiopia.Scientific reports · 2026Article
- Prevalence of nosocomial infections and antibiotic resistance patterns in Iranian hospitals over five years.Scientific reports · 2026Article
- Burden and Economic Impact of Antimicrobial Resistance inThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026Article
- Temporal Trends in Antimicrobial Resistance in a Tertiary Hospital in Western Guangxi, China: A Five-Year Surveillance Study (2021-2025).Infection and drug resistance · 2026Article
- Antibiotic resistance inFrontiers in microbiology · 2026Review
- Patients and Surfaces: Integrated Clinical-Environmental Surveillance of MDR Gram-Negative Bacteria in Critical-Care Units (Karachi, 2024-2025).Microorganisms · 2025Article
- Review
- Coexistence of carbapenem resistance and hypervirulence in clinical Klebsiella pneumoniae isolates: a molecular and phenotypic analysis.BMC infectious diseases · 2025Article
- Global burden and trends ofFrontiers in public health · 2025Article
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Abstract
backgroundIn the past decades, the prevalence of carbapenem-resistant Gram-negative bacteria (CR-GNB) has increased on a global scale. Here, we outline the infection prevention and control (IPC) interventions for addressing the prevalence of carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-resistant Klebsiella pneumoniae (CRKP).
methodsA quasi-experimental study design was performed during the seven periods of 6-months from September 2018 to September 2021 in a large ICU in an Iranian hospital. IPC interventions were implemented from period 2 onward, with the exception of period 4 (March-September 2020) due to COVID-19 pandemic-related service disruptions. CRKP and CRAB prevalence and antibiotic resistance of GNB were compared across the seven periods.
resultsIn total, 1,862 GNB isolates were identified across seven periods, with K. pneumoniae (41%) being the most prevalent pathogen, followed by Escherichia coli (24.6%) and A. baumannii (14%). The highest antibiotic resistance rates, including 65.5% for meropenem, were observed during the fourth period. From September 2019 to March 2022, 178 CRKP and 97 CRAB isolates were identified, with infection rates of 78.1% and 62.9%, respectively. Following IPC interventions, a significant reduction in CRKP and CRAB prevalence was noted in the second and third periods, although an increase occurred during the fourth period. By the seventh period, the lowest prevalence of CRKP (26 isolates) and CRAB (5 isolates) was observed. Finally, a moderate inverse correlation (-0.571) was found between hand hygiene compliance and mortality incidence.
conclusionThe implementation of targeted IPC interventions significantly reduced the prevalence of CRKP and CRAB infections in the ICU, demonstrating their effectiveness in controlling antibiotic-resistant pathogens. However, the resurgence of these infections during the COVID-19 pandemic highlights the need for continuous monitoring and adaptation of IPC strategies. Ongoing training and adherence to hygiene protocols are essential to sustain improvements and prevent future outbreaks. Our findings underscore the importance of proactive infection control measures in managing antibiotic resistance in critical care settings.
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