ArticleJournal of orthopaedic surgery and research2025
Anterior tuberculosis lesion debridement and bone grafting combined with short-segment internal fixation in the treatment of thoracolumbar tuberculosis.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- miR-29a-3p targets the PI3K/Akt signaling pathway to suppress inflammation and MMP-9-dependent matrix degradation in spinal tuberculosis.Journal of orthopaedic surgery and research · 2026Article
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6 authors.
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Abstract
STUDY
designThis was a retrospective study.
objectiveTo retrospectively analyze the safety and efficacy of anterior lesion debridement and bone grafting combined with short-segment internal fixation for the treatment of patients with thoracolumbar tuberculosis. There is currently no unified standard in the academic community for surgical treatment of spinal tuberculosis. This study proposes a new surgical approach for specific thoracolumbar tuberculosis.
methodsPatients (n = 65) who underwent anterior lesion debridement and bone grafting combined with short-segment internal fixation at our institution between January 2011 and January 2021 were included in this study. The patients were followed up for at least 2 years. During each follow-up, patients were graded using the American Spinal Injury Association (ASIA) neurologic deficit grading system, and postoperative conditions were evaluated using the Oswestry Disability Index (ODI) and pain visual analog scale (VAS).
resultsAll patients successfully completed the surgery without serious complications.Four patients had unstable vital signs during the operation, 3 patients had a water-electrolyte imbalance in the postoperative period, 5 patients had transient neurological symptoms in the postoperative period, 1 patient had cerebrospinal fluid leakage after the operation, 1 patient had a transient nerve injury, and 1 patient had delayed healing. The patient with recurrence was treated regularly with quadruple antituberculosis drugs for three months after surgery and then maintained with two oral antituberculosis drugs for the following period. The CT examination was repeated half a year later, and all the indexes showed that the prognosis was good. The patients' mean postoperative VAS and ODI scores were significantly better than the preoperative scores.
conclusionAnterior tuberculosis lesion debridement and bone grafting combined with short-segment internal fixation in the treatment of thoracolumbar tuberculosis has certain advantages over other Surgical Procedures, and can achieve corresponding clinical results.
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