Evidence map›Paper›PMID 40361165›Full record

ArticleItalian journal of pediatrics2025

Comprehensive analysis of acute flaccid paralysis with and without myelitis in Taiwanese children.

Chien-Heng Lin, Ru-Huei Fu, I-Ching Chou, Yu-Tzu Chang, Syuan-Yu Hong

Abstract readComparative Study
In one paragraph

Article in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chien-Heng Lin *Division of Pediatrics Pulmonology, China Medical University Children's Hospital, Taichung, 40447, Taiwan.
Ru-Huei Fu *Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 40402, Taiwan.
I-Ching ChouDivision of Pediatric Neurology, China Medical University Children's Hospital, Taichung, 40447, Taiwan.
Yu-Tzu ChangDivision of Pediatric Neurology, China Medical University Children's Hospital, Taichung, 40447, Taiwan.
Syuan-Yu HongGraduate Institute of Biomedical Sciences, China Medical University, Taichung, 40402, Taiwan. dazingdog@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute flaccid paralysis (AFP) is a clinical syndrome marked by the sudden onset of muscle weakness or paralysis, requiring immediate medical intervention due to its potential for significant morbidity and mortality. Despite extensive studies on AFP, comparative analyses between cases with myelitis (M-AFP) and non-myelitis (NM-AFP) remain scarce. This study seeks to address this gap by analyzing demographic, clinical, and etiological distinctions between these groups.

methodsA retrospective study was conducted on 39 pediatric AFP patients diagnosed between 2012 and 2021. Participants were categorized into M-AFP (n = 22) and NM-AFP (n = 17) groups based on clinical symptoms and diagnostic imaging. Demographic and clinical characteristics, laboratory findings, and underlying causes were analyzed to identify differences between the groups. Statistical methods were employed to assess significance.

resultsSignificant clinical differences were observed: limb numbness was more prevalent in M-AFP, while myalgia was more common in NM-AFP. Elevated cerebrospinal fluid white blood cell (CSF WBC) counts were noted in M-AFP cases, though the difference was not statistically significant. Etiologies of M-AFP included multiple sclerosis and enterovirus infections, while NM-AFP involved polymyositis, Guillain-Barré syndrome, and hypokalemic periodic paralysis.

conclusionsThis study highlights the distinct clinical and etiological profiles of M-AFP and NM-AFP, emphasizing the need for tailored diagnostic strategies to enhance outcomes in pediatric patients.

Indexed as

MyelitisNeuromuscular DiseasesParalysisAcute DiseaseAdolescentCentral Nervous System Viral DiseasesChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesTaiwanAcute flaccid paralysisChildrenMyelitis

Identifiers

PMID40361165
PMCPMC12077078

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.