Evidence map›Paper›PMID 40361148›Full record

ArticleBMC veterinary research2025

The impact of dietary salt on the development of hypertension and gut microbiome dysbiosis in captive-bred vervet monkeys (Chlorocebus aethiops).

Zandisiwe Emilia Magwebu, Sanele Khoza, Mikateko Mazinu, Esme Jordaan, Meenu Ghai, Chesa Gift Chauke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Foods (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zandisiwe Emilia MagwebuPrimate Unit and Delft Animal Centre (PUDAC), South African Medical Research Council, Tygerberg, Cape Town, South Africa. Zandisiwe.Magwebu@mrc.ac.za.
Sanele KhozaPrimate Unit and Delft Animal Centre (PUDAC), South African Medical Research Council, Tygerberg, Cape Town, South Africa.
Mikateko MazinuBiostatistics Research Unit, South African Medical Research Council, Tygerberg, Cape Town, South Africa.
Esme JordaanBiostatistics Research Unit, South African Medical Research Council, Tygerberg, Cape Town, South Africa.
Meenu GhaiSchool of life Sciences, College of Agriculture, Engineering and Science, University of KwaZulu-Natal, Westville, South Africa.
Chesa Gift ChaukePrimate Unit and Delft Animal Centre (PUDAC), South African Medical Research Council, Tygerberg, Cape Town, South Africa.

Funding

National Research Foundation UID 113583
6 · The paper itself

Abstract

backgroundThe study was designed to establish a hypertensive nonhuman primate model to evaluate the role of dietary salt intake on blood pressure levels and gut microbiome regulation. Sixteen adult vervet monkeys were selected and assigned into two groups (control and experimental). The control group was given a maintenance diet (100 g), whereas the diet of the experimental group was supplemented with 1.5 g/day of dietary salt in the mornings for six months (T

resultsThe control group was borderline hypertensive (134.7/62.9 mmHg), whereas elevated blood pressure levels (171.3/81.3 mmHg) were observed at T

conclusionThese findings suggested that dietary salt intake (1.5-2 g/day) caused alterations in systolic blood pressure levels, chloride and alkaline phosphatase (ALP). However, these changes were not associated with gut microbiome dysbiosis even though significant changes were observed over time for the individual groups.

Indexed as

DysbiosisGastrointestinal MicrobiomeHypertensionMonkey DiseasesSodium Chloride, DietaryAnimalsBlood PressureChlorocebus aethiopsDietFecesFemaleMaleSodium Chloride, DietaryAnd FirmicutesBacteroidetesBlood pressureMicrobiome diversityNonhuman primatesSalt sensitivity

Identifiers

PMID40361148
PMCPMC12070606

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.