ArticleBMC pediatrics2025
Lipid metabolism dysregulation in umbilical cord plasma of newborns from mothers with preeclampsia is associated with neonatal physical parameters at birth.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Combined cord blood metabolomic and clinical signatures discriminate small for gestational age neonates in preeclampsia.Frontiers in endocrinology · 2026Article
- Multi-Omics Reveal That Gut Microbial Dysbiosis Drives Lipid Metabolic Disturbances and Inflammation in Gestational Hypertension.Journal of inflammation research · 2025Article
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10 authors.
Funding
Abstract
backgroundPreeclampsia is linked to fetal growth restriction and may have long-term implications for the offspring. Despite its significance, the fundamental mechanisms remain inadequately elucidated. The objective of this investigation was to undertake an untargeted lipidomics analysis of umbilical cord plasma, with the intention of investigating lipidomic profile alterations in newborns of mothers with preeclampsia and evaluating the associations between lipidomic patterns and neonatal physical parameters at birth.
methods25 newborns from mothers with preeclampsia (PE group) and 25 newborns from healthy mothers (control group) were involved in the present investigation. Untargeted lipidomics was performed using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to contrast the lipid compositions present in umbilical cord plasma. Co-expression correlation analysis was performed to explore the relationships between lipidomic patterns and neonatal weight and length percentile at birth.
resultsMarked discrepancies in lipid metabolism profiles were detected in the comparison of the PE and control groups. In total, 364 separate lipids were noted, with AcylGlcADG (20:3-22:6-22:6) and GM3(d39:1) exhibiting the most significant decreases. Conversely, Cer-NS (d20:1-24:0) and DGTS (2:0-19:0) displayed the most significant increases. The primary lipid metabolic pathways altered in newborns from mothers with preeclampsia were enriched in choline and glycerophospholipid metabolic processes. Additionally, 20 distinct lipids exhibited significant associations with neonatal birth weight percentile between the two groups, while 21 distinct lipids showed significant associations with neonatal birth length percentile.
conclusionsLipid profile disorders were identified in the umbilical cord plasma of infants born to mothers with preeclampsia, and the metabolic disturbances identified in this group correlated with neonatal physical parameters at birth. These findings suggest that lipidomic disorders in newborns from preeclamptic mothers may correlate with intrauterine growth outcomes.
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