Evidence map›Paper›PMID 40361071›Full record

ArticleBMC biology2025

Admixture and selection offer insights for the conservation and breeding of Guyuan cattle.

Shuang Liu, Huixuan Yan, Xue Feng, Xiaoyu Luo, Yang Lv, Chuzhao Lei, Ningbo Chen, Yun Ma

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Shuang Liu *Key Laboratory of Molecular Cell Breeding of Ruminants in Ningxia Hui Autonomous Region, College of Animal Science and Technology, Ningxia University, Yinchuan, 750021, China.
Huixuan Yan *Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Xue Feng *Key Laboratory of Molecular Cell Breeding of Ruminants in Ningxia Hui Autonomous Region, College of Animal Science and Technology, Ningxia University, Yinchuan, 750021, China.
Xiaoyu LuoKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Yang LvCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Chuzhao LeiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China. leichuzhao1118@nwafu.edu.cn.
Ningbo ChenKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China. ningbochen@nwafu.edu.cn.
Yun MaKey Laboratory of Molecular Cell Breeding of Ruminants in Ningxia Hui Autonomous Region, College of Animal Science and Technology, Ningxia University, Yinchuan, 750021, China. mayun@nxu.edu.cn.

Funding

Key Research and Development Program of Ningxia 2023BCF01006National Natural Science Foundation of China 32341054National Natural Science Foundation of China U22A20506National Science and Technology Major Project 2023ZD0404803-02the earmarked fund for the China Agriculture Research System of MOF and MARA CARS-37
6 · The paper itself

Abstract

backgroundThe admixture between taurine and indicine cattle increases breed diversity and provides new genetic resources for human and natural selection. The climate of northwestern China is typified by cold and arid conditions, and cattle in this region are primarily taurine breeds. However, Guyuan cattle inhabit a transitional zone in northwestern China, typified by semi-arid and semi-humid climates. It is hypothesized that Guyuan cattle have a little of indicine ancestry. These results suggest that Guyuan cattle are a valuable genetic resource.

resultsWe established a conservation population of Guyuan cattle in their native habitat. We found that Guyuan cattle were an admixture between 78.09% East Asian taurine (EAT) and 20.26% East Asian indicine (EAI) ancestries. The admixture in Guyuan cattle was dated to 255 years ago. Notably, we identified Guyuan cattle as a unique genetic resource, representing a transitional breed between northern and central Chinese cattle with distinct admixture proportions. We revealed that the selection signals in Guyuan cattle with excess EAT ancestry were associated with reproduction, immunity, body length, cold climate adaptation, pigmentation, muscle development, residual feed intake, and fat deposition and that the selection signals in Guyuan cattle with excess EAI ancestry were associated with disease resistance. Remarkably, we discovered valuable single nucleotide polymorphisms (SNPs) in the promoter regions of the RBM39 and NEK6 genes, which may play key roles in regulating muscle development and disease resistance.

conclusionsOur results suggest that Guyuan cattle are a newly identified genetic resource, and the native taurine and indicine ancestries in Guyuan cattle remain a valuable genetic resource of conservation and breeding.

Indexed as

BreedingConservation of Natural ResourcesSelection, GeneticAnimalsCattleChinaPolymorphism, Single NucleotideAdmixtureConservation populationDisease resistanceGuyuan cattleMuscle developmentSelection

Identifiers

PMID40361071
PMCPMC12077033

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.