Evidence map›Paper›PMID 40361003›Full record

Observational studyBMC nephrology2025

Outcome of proliferative lupus nephritis with thrombotic microangiopathy; An ambispective observational single-center study.

Ahmed Fayed, Rasmia Elgohary, Amr Mohamed Shaker, Karem Mohamed Salem, Eman El Desouky, Gehad Gamal Maghraby

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ahmed FayedNephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt.
Rasmia ElgoharyRheumatology and Clinical Immunology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt.
Amr Mohamed ShakerNephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt.
Karem Mohamed SalemNephrology Unit, Internal Medicine Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Eman El DesoukyDepartment of Epidemiology and Biostatistics, National Cancer Institute, Cairo University, Cairo, Egypt.
Gehad Gamal MaghrabyRheumatology and Clinical Immunology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt. gehad.maghraby@kasralainy.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThrombotic microangiopathy (TMA) represents a broad spectrum of diseases. The combination of TMA with lupus nephritis (LN) is associated with worse renal outcomes and a higher mortality rate. To date, there is no agreement on the therapeutic strategies that should be offered to TMA-LN patients.

objectiveIn this study, we compared the long-term outcomes of plasma exchange (PLEX) and cyclophosphamide (CYC) in a TMA-LN cohort.

methods100 TMA-LN patients who received an induction of steroids and either PLEX or CYC less than 3 months from the start of the study, were selected from the medical records of Kasr Alainy hospitals, Cairo University. The patients were monitored for hematological and renal response at 3, 6, and 12 months.

findingsIn PLEX arm, the mean creatinine level was 1.4 ± 0.7 mg/dl at baseline, decreased to 1.1 ± 0.5 mg/dl after 3 months, and returned to 1.4 ± 1.4 mg/dl at 6 and 12 months (p = 0.748). Proteinuria levels significantly decreased from 2.9 ± 0.7 9 gm/24 hrs at baseline to 0.4 ± 0.5 9 gm/24 hrs after 12 months (p < 0.001). PLT significantly increased over time with a mean of 65.6 ± 19.0 (x10

conclusionBoth groups demonstrated significant improvements in renal and hematological outcomes with better long-term renal outcomes in the PLEX arm and comparable improvements in the hematological measures in both groups.

Indexed as

CyclophosphamideLupus NephritisPlasma ExchangeThrombotic MicroangiopathiesAdultFemaleHumansImmunosuppressive AgentsMaleMiddle AgedRetrospective StudiesTreatment OutcomeYoung AdultCyclophosphamideImmunosuppressive AgentsCyclophosphamideLupus nephritisPlasmapheresisSystemic lupus erythematosusThrombotic microangiopathy

Identifiers

PMID40361003
PMCPMC12076891

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.