Evidence map›Paper›PMID 40360942›Full record

ArticleEJNMMI radiopharmacy and chemistry2025

Evaluation of in vivo and in vitro binding property of a novel candidate PET tracer for CSF1R imaging and comparison with two currently-used CSF1R-PET tracers.

Xiyan Rui, Yuzhou Ding, Nailian Zhang, Xinran Zhao, Chie Seki, Tomoteru Yamasaki, Masayuki Fujinaga, Ming-Rong Zhang, Jun Qian, Bin Ji and 1 more

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In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Illuminating proinflammatory myeloid cells with PET tracers targeting GPR84.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Xiyan Rui *Department of Nephrology, Yangpu Hospital, School of Medicine, Tongji University, 450 Tengyue Road, Shanghai, 200090, China.
Yuzhou Ding *Department of Radiopharmacy and Molecular Imaging, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
Nailian ZhangDepartment of Radiopharmacy and Molecular Imaging, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
Xinran ZhaoDepartment of Radiopharmacy and Molecular Imaging, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
Chie SekiAdvanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan.
Tomoteru YamasakiDepartment of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Masayuki FujinagaDepartment of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Ming-Rong ZhangDepartment of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Jun QianDepartment of Radiopharmacy and Molecular Imaging, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
Bin JiDepartment of Radiopharmacy and Molecular Imaging, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China. binji@fudan.edu.cn.
Rong ZhouDepartment of Nephrology, Yangpu Hospital, School of Medicine, Tongji University, 450 Tengyue Road, Shanghai, 200090, China. zhourong@tongji.edu.cn.ORCID http://orcid.org/0000-0003-0004-8621

Funding

National Natural Science Foundation of China 82394433/82361148130
6 · The paper itself

Abstract

backgroundColony-stimulating factor 1 receptor (CSF1R) is a promising imaging biomarker for neuroinflammation and tumor-associated macrophages. However, existing positron emission tomography (PET) tracers for CSF1R imaging often suffer from limited specificity or sensitivity.

resultsWe have performed

conclusionsThese results suggest that [

Indexed as

[11C]CPPC[11C]o-aminopyridyl alkynyl derivativeAutoradiographyColony-stimulating factor 1 receptor (CSF1R)Positron emission computed tomography (PET)

Identifiers

PMID40360942
PMCPMC12075084

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.