Evidence map›Paper›PMID 40360906›Full record

Observational studyEuropean radiology experimental2025

Marc Jonuscheit, Benedict Korzekwa, Michael Schär, Julian Mevenkamp, Stefan Wierichs, Pavel Bobrov, Theresia Sarabhai, Sabine Kahl, Michael Roden, Vera B Schrauwen-Hinderling

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in European radiology experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01055093 (Prospective Study on Diabetes Mellitus and Its Complications in Newly Diagnosed Adult Patients), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01055093 recruitingnot on this map

Prospective Study on Diabetes Mellitus and Its Complications in Newly Diagnosed Adult Patients

TypeobservationalSponsorGerman Diabetes CenterRan2005 to 2040Enrolled2,000ConditionsDiabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Systemic Inflammation and Peripheral T Cell Responses Associate With Hepatic Energy Metabolism in Recent-Onset Type 1 Diabetes.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  3. Recent Advances in Musculoskeletal Radiology: Bridging Innovation and Clinical Application.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marc JonuscheitInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Benedict KorzekwaInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Michael SchärDivision of Magnetic Resonance Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, United States of America.
Julian MevenkampDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Stefan WierichsInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Pavel BobrovGerman Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, München-Neuherberg, Germany.
Theresia SarabhaiInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Sabine KahlInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Michael RodenInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Vera B Schrauwen-HinderlingInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany. vera.schrauwen-hinderling@ddz.de.ORCID http://orcid.org/0000-0001-7795-584X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsA prospective single-center study was performed (January 2023-August 2024) within the German Diabetes Study. We established a suitable

resultsReproducibility assessment in nine CON, aged 27 ± 4 years (mean ± standard deviation), yielded coefficients of variation for repeated measurements of 7.1% and 21.3% for

conclusionThis RELEVANCE STATEMENT: Noninvasive methods to investigate hepatic energy metabolism are urgently needed to evaluate liver health while preventing unnecessary biopsies. For broad clinical applicability, the robustness shown by the proposed method at clinical field strength is crucial.

trial registrationClinicalTrials.gov: NCT01055093-Prospective study on diabetes mellitus and its complications in newly diagnosed adult patients (GDC), NCT01055093, Registered: 01/22/2010, https://clinicaltrials.gov/study/NCT01055093?term=NCT01055093&rank=1#study-overview . KEY POINTS: The proposed magnetic resonance spectroscopy method calculates hepatic ATP synthesis rates at clinical field strength. The protocol shows acceptable reproducibility and spectra without contamination from muscle. The method can detect differences between participants with type 1 diabetes and controls.

Indexed as

Adenosine TriphosphateLiverAdultDiabetes Mellitus, Type 1Energy MetabolismFemaleHumansMagnetic Resonance SpectroscopyMaleProspective StudiesReproducibility of ResultsAdenosine TriphosphateAdenosine triphosphateDiabetes mellitus (type 1)Energy metabolismLiverMagnetic resonance spectroscopy

Identifiers

PMID40360906
PMCPMC12075714

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.