Evidence map›Paper›PMID 40360886›Full record

ArticleJournal of natural medicines2025

Ginsenoside Rh3-induced neurotoxicity involving the IP3R-Ca

Yuheng Wang, Jianwen Chen, Song Li, Zhengxu Cai

Abstract read
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Article in Journal of natural medicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Mechanism of LTXInternational journal of molecular sciences · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuheng Wang *Department of Neurology, The First Affiliated Hospital, Dalian Medical University, Dalian, 116011, China.
Jianwen Chen *Department of Neurology, The First Affiliated Hospital, Dalian Medical University, Dalian, 116011, China.
Song LiKey Laboratory of Liaoning Province for Research On the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, 116011, China.
Zhengxu CaiDepartment of Neurology, The First Affiliated Hospital, Dalian Medical University, Dalian, 116011, China. caizhengxu999@126.com.

Funding

Dalian Peak Plan project DF2023021Dalian Peak Plan project DF2023023
6 · The paper itself

Abstract

Ginsenoside Rh3, a bioactive component of ginsenosides, has gained attention for its potential therapeutic effects, especially in cancer treatment. However, its neurotoxic effects remain poorly characterized, raising concerns about its safety for clinical use. This study investigates the neurotoxic effects of ginsenoside Rh3 and explores the underlying mechanisms. We demonstrate that ginsenoside Rh3 induces significant cytotoxicity in Neuro-2a and C8-D1A cells, as confirmed by methyl thiazolyl tetrazolium (MTT) assays, live-dead staining, and lactate dehydrogenase (LDH) release assays. Neurotoxicity polymerase chain reaction (PCR) array analyses show that the cytotoxicity of ginsenoside Rh3 in Neuro-2a cells involves calcium ion transport, oxidative stress, inflammation, and programmed cell death (PCD). Specifically, ginsenoside Rh3 elevates intracellular Ca

Indexed as

CalciumGinsenosidesInositol 1,4,5-Trisphosphate ReceptorsNADPH Oxidase 2NF-kappa BSignal TransductionAnimalsApoptosisCell Line, TumorMiceMolecular Docking SimulationOxidative StressCalciumCybb protein, mouseGinsenosidesInositol 1,4,5-Trisphosphate ReceptorsNADPH Oxidase 2NF-kappa BApoptosisGinsenoside Rh3IP3R-Ca2+NeurotoxicityNOX2Oxidative stress

Identifiers

PMID40360886

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.