Evidence map›Paper›PMID 40360878›Full record

ArticleBiological trace element research2025

Syzygium cumini Fruit Extract and Quercetin Ameliorate Cadmium-Induced Ovarian Apoptosis in Rats Via miRNA- 204 - 5p-Mediated Bcl- 2 Upregulation and Bax/Caspase 9/Caspase 3 Downregulation.

Walaa I E Abdel-Badeea, Ahmed Abdel-Wahab, Ahmed A Mahmoud, Abdel-Razik H Abdel-Razik, Eman Z Attia, Usama R Abdelmohsen, Kamel M A Hassanin

Abstract read
In one paragraph

Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The effects of cadmium and high fructose diet on metabolic and reproductive health in female CD-1 mice.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Walaa I E Abdel-BadeeaBiochemistry Department, Faculty of Veterinary Medicine, Minia University, 61519, Minia, Egypt. walaa.vet@mu.edu.eg.
Ahmed Abdel-WahabPhysiology Department, Faculty of Veterinary Medicine, Minia University, 61519, Minia, Egypt.
Ahmed A MahmoudChemistry Department, Faculty of Sciences, Minia University, 61519, Minia, Egypt.
Abdel-Razik H Abdel-RazikHistology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt.
Eman Z AttiaPharmacognosy Department, Faculty of Pharmacy, Minia University, 61519, Minia, Egypt.
Usama R AbdelmohsenPharmacognosy Department, Faculty of Pharmacy, Minia University, 61519, Minia, Egypt.
Kamel M A HassaninBiochemistry Department, Faculty of Veterinary Medicine, Minia University, 61519, Minia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The correlation between exposure to environmental pollutants and adverse impacts on fertility has been documented. Cadmium (Cd) is one of the most toxic elements that impairs female reproductive capacity. Syzygium cumini is a plant that contains polyphenols with strong antioxidant properties. Our study aimed to investigate the possible protective effects of Syzygium cumini fruit extract (SCFE) and quercetin (QU) against Cd-induced ovarian toxicity and apoptosis in rats assisted by measuring oxidative stress markers, hormonal profile, intrinsic apoptotic pathway, miRNA-204-5p, and histopathology. For that, 45 adult female rats were divided randomly into five groups; control, cadmium chloride (CdCl

Indexed as

ApoptosisCadmiumFruitMicroRNAsOvaryPlant ExtractsQuercetinSyzygiumAnimalsAntioxidantsbcl-2-Associated X ProteinCaspase 3Down-RegulationFemaleOxidative StressProto-Oncogene Proteins c-bcl-2AntioxidantsBax protein, ratbcl-2-Associated X ProteinBcl2 protein, ratCadmiumCasp3 protein, ratCaspase 3MicroRNAsPlant ExtractsProto-Oncogene Proteins c-bcl-2QuercetinApoptosisCadmiumMicroRNAsQuercetinSyzygium

Identifiers

PMID40360878
PMCPMC12672602

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.