ArticleEvidence-based dentistry2025
Ozone therapy as a complementary approach in periodontal therapeutics.
Article in Evidence-based dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Adjunctive Gaseous Ozone Improves Clinical and Microbiological Outcomes in Periodontitis: A Randomized Split-Mouth Study.Dentistry journal · 2026Article
- Authors' Reply "Ozonized Hydrogel and Chlorhexidine Gel for Peri-Implant Mucositis: A 24-Month Randomized Controlled Trial".Oral diseases · 2026Article
- The use of ozone in oral health care: a narrative review of current evidence and clinical applications.Frontiers in oral health · 2026Review
- Twelve-Month Follow-Up After the Treatment of Periodontal Conditions Using Scaling and Root Planning Alone vs. Laser-Assisted New Attachment Procedure.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
a commentary onLiu J, Huang Y, Huang J, Yang W, Tao R. Effects of ozone therapy as an adjuvant in the treatment of periodontitis: a systematic review and meta-analysis. BMC Oral Health 2025; 25: 335. DATA SOURCES: The authors conducted a systematic search across: 1. PubMed (MEDLINE); 2. Embase; 3. Cochrane Central Register of Controlled Trials (CENTRAL). Key question Does adjunctive ozone therapy improve periodontal clinical parameters (probing depth, gingival inflammation, bleeding, plaque levels, and attachment loss) in patients with chronic periodontitis compared to conventional scaling and root planing (SRP) alone? The study follows the PICO framework: 1. POPULATION: Patients with chronic periodontitis; 2.
interventionSRP + ozone therapy (ozonated water or gaseous ozone); 3. Comparison: SRP + placebo (e.g., saline, distilled water) or no adjunct; 4. OUTCOMES: Probing depth (PD), gingival index (GI), bleeding on probing (BOP), plaque index (PI), and clinical attachment level (CAL). SEARCH STRATEGY: Combined Medical Subject Headings (MeSH) terms and free-text keywords related to ozone ("Ozone," "Ozonated water," "Gaseous ozone") and periodontitis ("Chronic periodontitis," "Periodontal therapy"). STUDY SELECTION: Inclusion criteria: Study Design: 1. Only randomized controlled trials (RCTs); 2.
participantsAdults with chronic periodontitis (no systemic diseases or pregnancy). 3.
interventionSRP + ozone therapy (either ozonated water irrigation or gaseous ozone insufflation). 4. CONTROL: SRP + placebo (e.g., saline, distilled water) or no adjunct. 5. OUTCOMES: At least one of the following-PD, GI, BOP, PI, or CAL. EXCLUSION CRITERIA: 1. Animal/in vitro studies; 2. Studies involving antibiotics, lasers, or other adjuncts; 3. Incomplete data or non-RCT designs. Screening process: 1. Initial Search: 99 records identified; 2. After Duplicate Removal: 62 studies screened; 3. Full-Text Review: 22 articles assessed, 13 met inclusion criteria. Final included studies: 1. 8 used ozonated water (concentration range: 2-85 μg/mL); 2. 5 used gaseous ozone (varying exposure times); 3. Follow-up periods: 4 weeks to 3 months. DATA EXTRACTION AND SYNTHESIS: Data collection: 1. Two independent reviewers extracted data to minimize bias; 2. Extracted variables: study design, sample size, ozone concentration, application method, follow-up duration, and clinical outcomes. STATISTICAL ANALYSIS: 1. Primary effect measure: weighted mean difference (WMD) with 95% confidence intervals (CI). 2. Heterogeneity assessed via I
results1. Probing Depth (PD) reduction: (a) 12 studies, 655 patients. (b) Significant improvement (WMD = -0.26 mm, P = 0.01). (c) Heterogeneity: High (I
conclusions1. Ozone therapy along with SRP is superior to SRP alone in reducing PD and GI, suggesting benefits in pocket depth and inflammation control. 2. No significant effects on BOP, PI, or CAL, indicating ozone may not improve all periodontal parameters. 3. Safe & well-tolerated: no adverse events reported.
Indexed as
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40360819What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.