Evidence map›Paper›PMID 40360778›Full record

ArticleCell biology and toxicology2025

Activation of CaMKII

Xuehan Li, Zhixiong Ma, Xueliang Liu, Chen Chen, Ziqing Yu, Di Sang, Tongfei Wang, Eric Erquan Zhang, Guangyou Duan, Dapeng Ju and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xuehan LiDepartment of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Zhixiong MaChinese Institute for Brain Research, Beijing, China. mazhixiong@cibr.ac.cn.
Xueliang LiuDepartment of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Chen ChenNational Institute of Biological Sciences, Beijing, China.
Ziqing YuNational Institute of Biological Sciences, Beijing, China.
Di SangNational Institute of Biological Sciences, Beijing, China.
Tongfei WangChinese Institute for Brain Research, Beijing, China.
Eric Erquan ZhangNational Institute of Biological Sciences, Beijing, China.
Guangyou DuanDepartment of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Dapeng JuDepartment of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. judapeng@cqmu.edu.cn.
He HuangDepartment of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. huanghe@cqmu.edu.cn.

Funding

the generous support of the Ministry of Science and Technology of China 2021ZD0203400the National Natural Science Foundation of China 31971090
6 · The paper itself

Abstract

General anesthesia (GA) is an essential clinical and surgical adjunct, widely recognized as the result of coordinated networks among numerous brain regions. Anesthetic drugs with different characteristics are associated with distinct networks of brain regions involved in anesthesia. Ciprofol, a novel intravenous anesthetic derived from structural modifications of propofol, has shown promise in clinical applications. However, the specific neuronal circuits and brain regions mediating their actions may differ. Moreover, the core brain regions that mediate the common anesthetic effects of these drugs remain unclear. In this research, we identified a central ensemble of brainstem neurons within the paramedian raphe nucleus (PMnR) using c-Fos staining in mice subjected to GA induced by continuous intravenous infusion of ciprofol and propofol. This neuronal population, primarily composed of CaMKIIa and Gad1-expressing cells, demonstrated consistent activation in reaction to ciprofol. Optogenetic activation of PMnR

Indexed as

Anesthesia, GeneralCalcium-Calmodulin-Dependent Protein Kinase Type 2NeuronsRaphe NucleiAnimalsMaleMiceMice, Inbred C57BLPropofolCalcium-Calmodulin-Dependent Protein Kinase Type 2PropofolChemogeneticCiprofolElectroencephalogramGeneral anesthesiaIn situ sequencingOptogeneticsParamedian raphe nucleusPropofol

Identifiers

PMID40360778
PMCPMC12075403

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.