GuidelineNature metabolism2025
Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution.
Abstract readGuidelineReview
In one paragraph
Guideline in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Review
- Surface protein profiling reveals depot-specific features of subcutaneous and visceral adipose progenitor cells.Biochemistry and biophysics reports · 2026Article
- Review
- Understanding adipocyte heterogeneity across species, depot, and disease.Biochemical Society transactions · 2026Review
- Adipocyte Expression of O-Glycoprotein Procollagen C-Endopeptidase Enhancer Protein 2 (PCPE2): Mechanisms Linking Fibrosis and Beiging of White Adipose Tissue.bioRxiv : the preprint server for biology · 2026Article
- Regulatory T cells establish an IL-10-IL10Rα immunometabolic checkpoint that limits HSL activation and lipolysis.bioRxiv : the preprint server for biology · 2026Article
- Perspectives on human adipose tissue: from cellular mechanisms to clinical complications.Diabetologia · 2026Review
- Dysfunctional adipose tissue-lymphatic crosstalk in obesity.Nature reviews. Endocrinology · 2026Review
- Obesity and Cancer: From Systemic Metabolic Reprogramming to Immunotherapy Paradox.Metabolites · 2026Review
- Single cell transcriptomics of human weight loss links adipocyte NPY1R to control of lipolysis.Molecular metabolism · 2026Article
- Heterogeneity and Clinical Relevance of Human Adipose Stromal and Progenitor Cells.Diabetes & metabolism journal · 2026Review
- Defining the vascular niche of human adipose tissue across metabolic states.Nature metabolism · 2026Article
- Scalable and comprehensive mosaic variant calling using DRAGEN.medRxiv : the preprint server for health sciences · 2026Article
- Bridging the variant-to-function gap in type 2 diabetes: advances and challenges.Diabetologia · 2026Review
- Advances in the Role of Adipose Tissue in Promoting Injury Repair and Resist Infection.Immunity, inflammation and disease · 2026Review
- Inflammation and Resolution in Obesity-Related Cardiovascular Disease.International journal of molecular sciences · 2026Review
- Single-cell-resolved transcriptional dynamics of human subcutaneous adipose tissue during lifestyle- and bariatric surgery-induced weight loss.Nature metabolism · 2026Article
- Perithyroidal Adipose Tissue Drives Thyroid Tumorigenesis through Adipokine Signaling and Immune Suppression.Research (Washington, D.C.) · 2026Article
- Lipid-Associated Macrophages in Obesity: Immunometabolic Programs and Emerging Therapeutic Implications-A Narrative Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- White and brown adipose tissue share a convergent fibro-adipogenic progenitor population.EMBO reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
66 authors.
Anne LoftCenter for Functional Genomics and Tissue Plasticity (ATLAS), Department of Biochemistry and Molecular Biology, University of Southern Denmark (SDU), Odense, Denmark. anlo@bmb.sdu.dk.ORCID http://orcid.org/0000-0002-5647-8295
Margo P EmontSection of Endocrinology, Diabetes and Metabolism, University of Chicago, Chicago, IL, USA. margo@uchicago.edu.ORCID http://orcid.org/0000-0001-9873-2784
Ada WeinstockDepartment of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-3619-3388
Adeline DivouxTranslational Research Institute, AdventHealth, Orlando, FL, USA.
Adhideb GhoshDepartment of Health Sciences and Technology, Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
Allon WagnerDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-5095-6009
Ann V HertzelDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, The University of Minnesota-Twin Cities, Minneapolis, MN, USA.
Babukrishna ManiyadathCenter for Functional Genomics and Tissue Plasticity (ATLAS), Department of Biochemistry and Molecular Biology, University of Southern Denmark (SDU), Odense, Denmark.
Bart DeplanckeLaboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-9935-843X
Boxiang LiuDepartment of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-2595-4463
Camilla ScheeleNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6055-9709
Carey LumengDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
Changhai DingZhujiang Hospital, Southern Medical University, Guangzhou, China.
Chenkai MaHuman Health, Health and Biosecurity, CSIRO, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0003-2172-7332
Christian WolfrumDepartment of Health Sciences and Technology, Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.ORCID http://orcid.org/0000-0002-3862-6805
Clarissa Strieder-BarbozaDepartment of Veterinary Sciences, Texas Tech University, Lubbock, TX, USA.ORCID http://orcid.org/0000-0001-8824-4023
Congru LiDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7023-5962
Danh D TruongDepartment of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
David A BernlohrDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, The University of Minnesota-Twin Cities, Minneapolis, MN, USA.
Elisabet Stener-VictorinDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-3424-1502
Erin E KershawDepartment of Medicine, Division of Endocrinology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-3887-4868
Esti Yeger-LotemDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.ORCID http://orcid.org/0000-0002-8279-7898
Farnaz ShamsiDepartment of Molecular Pathobiology, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0003-3506-6950
Hannah X HuiSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0002-7525-5812
Henrique CamaraSection on Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Jiawei ZhongDepartment of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge, Huddinge, Sweden.ORCID http://orcid.org/0000-0002-2802-0770
Joanna KaluckaDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-4887-7672
Joseph A LudwigDepartment of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Julie A SemonDepartment of Biological Sciences, Missouri University of Science and Technology, Rolla, MO, USA.
Jutta JalkanenDepartment of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge, Huddinge, Sweden.ORCID http://orcid.org/0000-0002-0219-1096
Katie L WhytockTranslational Research Institute, AdventHealth, Orlando, FL, USA.ORCID http://orcid.org/0000-0003-3486-9452
Kyle D DumontMolecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0009-0009-4480-301X
Lauren M SparksTranslational Research Institute, AdventHealth, Orlando, FL, USA.ORCID http://orcid.org/0000-0002-8724-6016
Lindsey A MuirDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Lingzhao FangCenter for Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark.
Lucas MassierHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-6199-2643
Luis R SaraivaSidra Medicine, Doha, Qatar.ORCID http://orcid.org/0000-0003-4079-0396
Marc D BeyerImmunogenomics and Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0001-9704-148X
Marc G JeschkeCentre for Burn Research, Hamilton Health Sciences Centre, Department of Surgery and Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada.
Marcelo A MoriDepartment of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID http://orcid.org/0000-0001-7112-5263
Mariana BoroniLaboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0003-3495-9917
Martin J WalshIcahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-8339-8285
Mary-Elizabeth PattiSection on Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8163-3429
Matthew D LynesMaineHealth Institute for Research, Scarborough, ME, USA.
Matthias BlüherHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0003-0208-2065
Mikael RydénDepartment of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-4785-1876
Natnael HamdaAstellas Pharma, Northbrook, IL, USA.
Nicole L SoliminiDepartment of Medical Oncology, Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0009-0007-0002-0975
Niklas MejhertDepartment of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1785-833X
Peng GaoDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4311-584X
Rana K GuptaDepartment of Medicine, Division of Endocrinology, and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0002-9001-4531
Rinki MurphyDepartment of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0002-0043-2423
Saeed PirouzpanahMolecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Silvia CorveraUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-0009-4129
Su'an TangDepartment of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Swapan K DasDepartment of Internal Medicine, Section on Endocrinology and Metabolism, Medical Center Boulevard, Wake Forest University Health Sciences, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0002-2197-8855
Søren F SchmidtCenter for Functional Genomics and Tissue Plasticity (ATLAS), Department of Biochemistry and Molecular Biology, University of Southern Denmark (SDU), Odense, Denmark.
Tao ZhangSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-0315-7228
Theodore M NelsonDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.ORCID http://orcid.org/0000-0002-8600-0444
Timothy E O'SullivanDepartment of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-1435-8188
Vissarion EfthymiouDepartment of Health Sciences and Technology, Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
Wenjing WangDepartment of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.
Yihan TongDepartment of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.
Yu-Hua TsengSection on Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2053-9559
Susanne MandrupCenter for Functional Genomics and Tissue Plasticity (ATLAS), Department of Biochemistry and Molecular Biology, University of Southern Denmark (SDU), Odense, Denmark. s.mandrup@bmb.sdu.dk.ORCID http://orcid.org/0000-0002-0961-5787
Evan D RosenDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Broad Institute of MIT and Harvard, Cambridge, MA, USA. erosen@bidmc.harvard.edu.ORCID http://orcid.org/0000-0003-4603-708X
Funding
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI HU, FRANK B · 1992 to 2021
$25.0MInvestigating Human Adipocyte HeterogeneityRC2DK116691 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Orr Ashenberg, Noel P Burtt · 2018 to 2026
$17.8MP&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Deborah J Wexler · 2023 to 2026
$5.4MMechanisms of slits3 signaling in thermogenic adipose tissueR01DK136724 · NIDDK · NEW YORK UNIVERSITY · PI Farnaz Shamsi · 2024 to 2026
$1.5MThe role of vascular endothelium in BAT expansion and remodelingK01DK125608 · NIDDK · NEW YORK UNIVERSITY · PI SHAMSI, FARNAZ · 2020 to 2023
$644kInvestigating the regulation of distinct human adipocyte subpopulationsK01DK134806 · NIDDK · UNIVERSITY OF CHICAGO · PI Margo Preminger Emont · 2023 to 2026
$592kRegulation of Adipose Tissue Remodeling Through Axon Guidance Molecule Slit3R03DK135786 · NIDDK · NEW YORK UNIVERSITY · PI SHAMSI, FARNAZ · 2023 to 2024
$237kDanmarks Grundforskningsfond (Danish National Research Foundation) 141 (ATLAS)Lundbeckfonden (Lundbeck Foundation) R413-2022-471NIDDK NIH HHS K01 DK125608NIDDK NIH HHS K01 DK134806NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK135043NIDDK NIH HHS R01 DK136724NIDDK NIH HHS R03 DK135786NIDDK NIH HHS RC2 DK116691
Abstract
Adipose tissue (AT) is a complex connective tissue with a high relative proportion of adipocytes, which are specialized cells with the ability to store lipids in large droplets. AT is found in multiple discrete depots throughout the body, where it serves as the primary repository for excess calories. In addition, AT has an important role in functions as diverse as insulation, immunity and regulation of metabolic homeostasis. The Human Cell Atlas Adipose Bionetwork was established to support the generation of single-cell atlases of human AT as well as the development of unified approaches and consensus for cell annotation. Here, we provide a first roadmap from this bionetwork, including our suggested cell annotations for humans and mice, with the aim of describing the state of the field and providing guidelines for the production, analysis, interpretation and presentation of AT single-cell data.
Indexed as
Adipose TissueSingle-Cell AnalysisAdipocytesAnimalsAtlases as TopicHumansMice
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