ArticleCommunications biology2025
Emergence of a synergistic scaffold in the brains of human infants.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Frontal lead in preterm functional brain maturation.Developmental cognitive neuroscience · 2026Article
- Early development of cortical networks is modulated by Family Nurture Intervention: a multicenter replication study.Pediatric research · 2026Article
- Quantifying Cortical Maturational Aspects During Different Vigilance States in Preterm Infants by Advanced EEG Analysis.Journal of sleep research · 2026Article
- Charting higher-order models of brain function beyond pairwise interactions.Nature communications · 2026Article
- Structural signatures of synergy and redundancy in human brain function.bioRxiv : the preprint server for biology · 2026Article
- Maturation of Neuronal Activity in the Human Cortex Exhibits Robust Spatial Gradients across the Birth Transition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Understanding the high-order network plasticity mechanisms of ultrasound neuromodulation.PLoS computational biology · 2025Article
- Time-varying synergy/redundancy dominance in the human cerebral cortex.Journal of physics. Complexity · 2025Article
- Markers of consciousness in infants: Towards a 'cluster-based' approach.Acta paediatrica (Oslo, Norway : 1992) · 2025Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human brain is a complex organ comprising billions of interconnected neurons, which enables interaction with both physical and social environments. Neural dynamics of the whole brain go far beyond just the sum of its individual elements; a property known as "synergy". Previously it has been shown that synergy is crucial for many complex brain functions and cognition, however, it remains unknown how and when the large number of discrete neurons evolve into the unified system able to support synergistic interactions. Here we analyzed high-density electroencephalography data from the late fetal period to one month after term age. We found that the human brain transitions from a redundancy-dominated to a synergy-dominated system around birth. Frontal regions lead the emergence of a synergistic scaffold comprised of overlapping subsystems, while the integration of sensory areas developed gradually, from occipital to central regions. Strikingly, early developmental trajectories of brain synergy were modulated by environmental enrichment associated with enhanced mother-infant interactions, and the level of synergy near term equivalent age was associated with later neurocognitive development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.