ArticleMolecular psychiatry2025
Deciphering the influence of socioeconomic status on brain structure: insights from Mendelian randomization.
Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Alcohol consumption and risk of cancer: a Mendelian randomization analysis of four biobanks and consortium data.BMC medicine · 2025Article
- Associations between common genetic variants and income provide insights about the socio-economic health gradient.Nature human behaviour · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
Socioeconomic status (SES) influences physical and mental health, however its relation with brain structure is less well documented. Here, we examine the role of SES on brain structure using Mendelian randomisation. First, we conduct a multivariate genome-wide association study of SES using educational attainment, household income, occupational prestige, and area-based social deprivation, with an effective sample size of N = 947,466. We identify 554 loci associated with SES and distil these loci into those that are common across those four traits. Second, using an independent sample of ~35,000 we provide evidence to suggest that SES is protective against white matter hyperintensities as a proportion of intracranial volume (WMHicv). Third, we find that differences in SES still afford a protective effect against WMHicv, independent of that made by cognitive ability. Our results suggest that SES is a modifiable risk factor, causal in the maintenance of cognitive ability in older-age.
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