Evidence map›Paper›PMID 40360723›Full record

SynthesisInternational journal of impotence research2026

Tribulus terrestris for management of patients with erectile dysfunction: a systematic review and meta-analysis of randomized trials.

Sally Suharyani, Bella Amanda, Jesselyn Angellee, William William, Timotius Ivan Hariyanto, Reny I'tishom

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in International journal of impotence research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sally SuharyaniAndrology Study Program, Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, 60132, Indonesia.
Bella AmandaAndrology Study Program, Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, 60132, Indonesia.
Jesselyn AngelleeAndrology Study Program, Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, 60132, Indonesia.ORCID http://orcid.org/0000-0002-6848-799X
William WilliamDepartment of Medical Biology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, 14440, Indonesia.
Timotius Ivan HariyantoFaculty of Medicine, Pelita Harapan University, Tangerang, Banten, 15811, Indonesia.
Reny I'tishomDepartment of Biomedical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, 60132, Indonesia. ritishom@fk.unair.ac.id.ORCID http://orcid.org/0000-0002-9971-7786

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tribulus terrestris is a medicinal herb purported to enhance reproductive function, particularly in instances of erectile dysfunction (ED). This study aims to assess the effectiveness and safety of administering Tribulus terrestris to patients with ED. We performed a systematic literature review in the Cochrane Library, Medline, Scopus, and Europe PMC databases utilizing particular keywords. The primary endpoint in this study is International Index of Erectile Function, that may be in abridged form (IIEF-5) or full form (IIEF-15). The outcomes of continuous variables were aggregated into the mean difference (MD) with corresponding 95% confidence intervals (95% CI) utilizing random-effects models. Eight studies were selected for inclusion. After the intervention with Tribulus terrestris, the IIEF-5 [MD 4.21, p < 0.00001] and IIEF-15 scores [MD 15.88, p = 0.0004] were markedly elevated compared to their pre-supplementation levels, as per our comprehensive analysis. Additionally, on both the IIEF-5 [MD 3.23 (95%CI 1.89, 4.58), p < 0.00001] and IIEF-15 [MD 14.44 (95%CI 5.75, 23.14), p = 0.001], Tribulus terrestris outperformed placebo. However, the two groups were not significantly different in terms of total testosterone levels. We observed no difference in the incidence of adverse events between Tribulus terrestris and placebo. Tribulus terrestris supplementation may offer benefits in improving erectile function among patients with ED with a relatively good safety profile.

Indexed as

Erectile DysfunctionPhytotherapyPlant ExtractsTribulusHumansMalePenile ErectionRandomized Controlled Trials as TopicTreatment OutcomePlant Extracts

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.