ArticleScientific reports2025
Targeted delivery of doxorubicin to B-cell lymphoma using monoclonal antibody-functionalized Chaetoceros biosilica.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Plasma-Corona Enabled Synthesis of Photonic Copper Sensor for the Detection of Ovarian Cancer Marker CA 125.Nanomaterials (Basel, Switzerland) · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of biogenic nanoparticles as targeted drug delivery systems has gained increasing attention for improving anticancer therapies. This study investigates the effectiveness of porous biosilica derived from the diatom Chaetoceros sp., functionalized with hydrophilic GPTMS, labeled with CD-19 antibody, and loaded with doxorubicin in targeting Raji cells, a B lymphoid cell line. Biosilica was extracted, purified, and modified for enhanced drug delivery. Characterization involved X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) analysis, zeta potential measurement, dynamic light scattering (DLS), Transmission Electron Microscopy (TEM), scanning electron microscopy (SEM), and Fourier-transform infrared (FT-IR) spectroscopy, followed by drug loading and release measurements. Cytotoxicity was assessed using the MTT assay and apoptosis tests, with Jurkat cells as non-target controls. Results confirmed successful GPTMS surface modification and revealed the amorphous structure of biosilica, with mean intraparticle pore sizes of 130 nm (BET). The drug loading capacity reached 53.92%. The system exhibited significant cytotoxic effects on Raji cells (IC
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