Evidence map›Paper›PMID 40360698›Full record

ArticleScientific reports2025

Age dependent susceptibility and immune responses to La Crosse virus infection in non-human primates.

Clayton W Winkler, Tyson A Woods, Aaron B Carmody, Katherine G Taylor, Rachel LaCasse, Dana Scott, Patrick W Hanley, Jamie Lovaglio, Karin E Peterson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Clayton W WinklerLaboratory of Neurological Infections and Immunity, Department of Intramural Research, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, National Institutes of Health, 903 S. 4th St., Hamilton, MT, 59840, USA. winklercw@niaid.nih.gov.
Tyson A WoodsLaboratory of Neurological Infections and Immunity, Department of Intramural Research, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, National Institutes of Health, 903 S. 4th St., Hamilton, MT, 59840, USA.
Aaron B CarmodyResearch Technologies Branch, Rocky Mountain Laboratories, Department of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Katherine G TaylorLaboratory of Neurological Infections and Immunity, Department of Intramural Research, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, National Institutes of Health, 903 S. 4th St., Hamilton, MT, 59840, USA.
Rachel LaCasseRocky Mountain Veterinary Branch, Rocky Mountain Laboratories, Department of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Dana ScottRocky Mountain Veterinary Branch, Rocky Mountain Laboratories, Department of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Patrick W HanleyRocky Mountain Veterinary Branch, Rocky Mountain Laboratories, Department of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Jamie LovaglioRocky Mountain Veterinary Branch, Rocky Mountain Laboratories, Department of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Karin E PetersonLaboratory of Neurological Infections and Immunity, Department of Intramural Research, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, National Institutes of Health, 903 S. 4th St., Hamilton, MT, 59840, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

La Crosse virus (LACV) is a primary cause of pediatric viral encephalitis in the United States but rarely causes disease in adults. We tested whether cynomolgus macaques displayed a similar age-dependent susceptibility to LACV. Immune responses from naïve or LACV infected weanling (9-15 months), juvenile (19-23 months) or adult (> 6 years) animals were measured and infected animals were monitored for disease. Naïve weanling animals had fewer dendritic cells in their blood and weaker induction of IFN-stimulated genes (ISG) and chemokines when PBMCs were stimulated in vitro. While no infected animals developed disease, the weaker innate response in naive weanlings correlated with increased viral RNA in plasma from 2 of 3 infected weanlings out to 7 days post infection (dpi). Activated CD8

Indexed as

Encephalitis, CaliforniaLa Crosse virusAge FactorsAnimalsAntibodies, NeutralizingAntibodies, ViralCallithrixCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDendritic CellsDisease SusceptibilityImmunity, InnateMacaca fascicularisMaleRNA, ViralAntibodies, NeutralizingAntibodies, ViralRNA, ViralAge-related susceptibilityImmune responseInterferon stimulated geneLa Crosse virusNon-human primateT cell

Identifiers

PMID40360698
PMCPMC12075599

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.