ArticleScientific reports2025
Comparison of blood metal ion levels in scoliosis patients following instrumented spinal fusion with cobalt-chromium and titanium alloy rods.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Early postoperative serum metal profiles and subsequent revision-related surgery after instrumented fusion for adolescent idiopathic scoliosis.International orthopaedics · 2026Article
- Guided posterior vertebral growth modulation. A novel fusionless technique for correction of adolescent idiopathic scoliosis in immature patients with removal of the implants at maturity.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Impact of Intramedullary Implants on Metallic Element Homeostasis in Children with Forearm Fractures.Journal of clinical medicine · 2025Article
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Authors and funding
7 authors.
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Abstract
Elevated blood metal ion levels have been reported in patients following instrumented spinal fusion. However, the relationship between blood metal ion levels and clinical and radiographic outcomes remains elusive. The purpose of this study was to compare blood metal ion levels in patients with scoliosis undergoing corrective fusion surgery utilizing either cobalt-chromium (CoCr) or titanium (Ti) alloy rods, as well as preoperative scoliosis patients. Additionally, we investigated patient- and surgery-related factors associated with blood metal ion levels. This retrospective cohort study included 59 patients with CoCr rods (CoCr group), 29 patients with Ti alloy rods (Ti group), and 17 preoperative patients (control group). Blood samples were collected at a mean of 63 months postoperatively for the CoCr group and 113 months postoperatively for the Ti group. Blood levels of Co, Cr, and Ti were measured by inductively coupled plasma mass spectrometry. Blood Co levels were significantly elevated in the CoCr group compared to the control group (p = 0.021), with no significant difference observed between the CoCr and Ti groups (CoCr group: 0.28 μg/L, Ti group: 0.21 μg/L, control group: 0.20 μg/L). However, blood Cr and Ti levels were found to be below the limit of quantification in all 105 individuals. Furthermore, a significant negative correlation was observed between blood Co levels and the postoperative follow-up duration. These findings underscore the medium-term safety rather than the concerns regarding blood metal ion levels following corrective fusion for scoliosis; however, prolonged and meticulous follow-up is imperative.
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