Evidence map›Paper›PMID 40360634›Full record

ArticleScientific reports2025

Recovery of ambulation in older adults undergoing fracture surgery for femoral metastasis: a multicenter retrospective cohort study.

Kanako Ito, Hirokazu Shimizu, Masatake Matsuoka, Tamotsu Soma, Daisuke Takahashi, Tomohiro Shimizu, Toshiyuki Nishimoto, Hiroaki Hiraga, Norimasa Iwasaki, Akira Iwata

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kanako ItoDepartment of Orthopaedic Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
Hirokazu ShimizuDepartment of Orthopaedic Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan. shimizu_hirokazu@nifty.com.ORCID http://orcid.org/0000-0002-3997-5900
Masatake MatsuokaDepartment of Orthopaedic Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
Tamotsu SomaDepartment of Musculoskeletal Oncology, NHO Hokkaido Cancer Center, 2- chōme-3-54, Kikusui 4 Jō, Shiroishi Ward, Sapporo, 003-0804, Hokkaido, Japan.
Daisuke TakahashiDepartment of Orthopaedic Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
Tomohiro ShimizuDepartment of Orthopaedic Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
Toshiyuki NishimotoDepartment of Orthopaedic Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
Hiroaki HiragaDepartment of Musculoskeletal Oncology, NHO Hokkaido Cancer Center, 2- chōme-3-54, Kikusui 4 Jō, Shiroishi Ward, Sapporo, 003-0804, Hokkaido, Japan.
Norimasa IwasakiDepartment of Orthopaedic Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.
Akira IwataDepartment of Orthopaedic Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Sapporo, Hokkaido, 060-8638, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fracture surgery for metastatic femur is frequently performed in older adults. In contrast to impending fracture (IF), complete pathological fracture (CF) renders patients bedridden during the preoperative period, which might affect the postoperative recovery of ambulation. Thus, we aimed to investigate the clinical significance of the recovery in older adults after fracture surgery for femoral metastasis, and predictors for recovery after CF. This multicenter retrospective study enrolled 146 adults aged ≥55 years undergoing surgery. A total of 78.1% (114/146) patients showed recovery; no association was observed between the presence of postoperative weight-bearing restriction and recovery (p = 0.50). The rate of chemotherapeutic intervention was higher in patients who had recovered compared to the others (52/114 vs. 8/32, p = 0.03). Non-recovery of ambulation was an independent poor prognostic factor for one-year suvival (hazard ratio, 1.85; 95% confidence interval, 1.06-3.22; p < 0.01). Subgroup analyses showed shorter preoperative waiting periods in the recovered patients than in the others (5.6 ± 0.6 vs. 7.9 ± 1.1; p = 0.03) among CF cases. Recovery of ambulation was a prognostic factor and was associated with postoperative chemotherapy. Shorter preoperative waiting time was associated with the recovery in patients with CF. Prompt surgical intervention should be considered when older adults develop CF due to femoral metastasis.

Indexed as

Bone NeoplasmsFemoral FracturesFemoral NeoplasmsFractures, SpontaneousRecovery of FunctionWalkingAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesComplete pathological fractureMetastatic femurMortality rateRecovery of ambulationWaiting time

Identifiers

PMID40360634
PMCPMC12075596

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.