ArticleScientific reports2025
Response surface optimization reveals monthly total flavonoid peaks in Ginkgo biloba leaves with corresponding DPPH scavenging activity.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A Narrative Review of Ginkgo Biloba Extract: Biological Function, Molecular Mechanisms, and Applications in Animal Production.Antioxidants (Basel, Switzerland) · 2026Review
- Extraction ofMolecules (Basel, Switzerland) · 2025Article
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5 authors.
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Abstract
The study investigated the influence of ethanol concentration, reflux time, and reflux temperature on the content of total flavonoids (TFs) in Ginkgo biloba (GB) leaves. The optimal extraction conditions were determined using the response surface (RS) methodology. The fluctuation of flavonoid content in ethanol extracts of GB leaves across different months was compared with these optimized extraction parameters. Additionally, we investigated the antioxidant activity against DPPH free radicals for the GB extract in the month with the highest flavonoid content. Following RS optimization, the optimal extraction conditions for GB flavonoids were identified as follows: extraction rate of 1.175% at 61 °C for 30 min using 77% ethanol. Under these optimized conditions, the total flavonoid content of GB exhibited a bi-peak pattern, peaking in May and August. The extract obtained in May showed superior DPPH free radical-scavenging ability. These findings provide valuable insights for selecting raw materials for future preparations of GB products.
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