Evidence map›Paper›PMID 40360460›Full record

ArticleNature communications2025

Improving AI models for rare thyroid cancer subtype by text guided diffusion models.

Fang Dai, Siqiong Yao, Min Wang, Yicheng Zhu, Xiangjun Qiu, Peng Sun, Cheng Qiu, Jisheng Yin, Guangtai Shen, Jingjing Sun and 9 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Genomics and Multi-Omics to Guide Clinical Management in Thyroid Cancer.International journal of molecular sciences · 2026
    Review
  2. Machine-Learning Microfluidic Minute-Scale Microorganism Metrics Monitoring(M6).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Fang Dai *Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0009-0007-0727-5655
Siqiong Yao *SJTU-Yale Joint Center of Biostatistics and Data Science, Technical Center for Digital Medicine, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, China. yaosiqiong@sjtu.edu.cn.ORCID http://orcid.org/0000-0001-6968-1586
Min WangDepartment of Critical Care Medicine, Jiuquan Hospital of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Jiuquan, Gansu, PR China.
Yicheng ZhuDepartment of Ultrasound, Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, PR China.
Xiangjun QiuDepartment of Automation, Tsinghua University, Beijing, PR China.
Peng SunDepartment of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Cheng QiuMedical college, Nantong University, Nantong, Jiangsu, PR China.
Jisheng YinShcool of Artificial Intelligence, University of Chinese Academy of sciences, Beijing, PR China.
Guangtai ShenXin'an League People's Hospital, Xing'an League, Inner Mongolia, PR China.
Jingjing SunDepartment of Ultrasound, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, PR China.
Maofeng WangDepartment of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, PR China.
Yun WangDepartment of Hepatobiliary pancreatic center, Xuzhou City Central Hospital, Xuzhou, Jiangsu, China.
Zheyu YangDepartment of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School of medicine, Shanghai, PR China.
Jianfeng SangNanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, PR China.
Xiaolei WangDepartment of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0000-0002-9750-1906
Fenyong SunDepartment of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, PR China. sunfenyong@263.net.ORCID http://orcid.org/0000-0003-4959-7138
Wei CaiDepartment of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School of medicine, Shanghai, PR China. caiwei@shsmu.edu.cn.ORCID http://orcid.org/0000-0002-4765-3370
Xingcai ZhangWorld Tea Organization, Cambridge, MA, USA. drzhangxingcai@outlook.com.ORCID http://orcid.org/0000-0001-7114-1095
Hui LuDepartment of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. huilu@sjtu.edu.cn.ORCID http://orcid.org/0000-0001-8347-0830

Funding

National Natural Science Foundation of China (National Science Foundation of China) Grant No. 62406191National Natural Science Foundation of China (National Science Foundation of China) Grant No.82302231Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) Grant No. 23JS1400700Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) Grant No. 23JS1400800
6 · The paper itself

Abstract

Artificial intelligence applications in oncology imaging often struggle with diagnosing rare tumors. We identify significant gaps in detecting uncommon thyroid cancer types with ultrasound, where scarce data leads to frequent misdiagnosis. Traditional augmentation strategies do not capture the unique disease variations, hindering model training and performance. To overcome this, we propose a text-driven generative method that fuses clinical insights with image generation, producing synthetic samples that realistically reflect rare subtypes. In rigorous evaluations, our approach achieves substantial gains in diagnostic metrics, surpasses existing methods in authenticity and diversity measures, and generalizes effectively to other private and public datasets with various rare cancers. In this work, we demonstrate that text-guided image augmentation substantially enhances model accuracy and robustness for rare tumor detection, offering a promising avenue for more reliable and widespread clinical adoption.

Indexed as

Artificial IntelligenceRare DiseasesThyroid NeoplasmsHumansUltrasonography

Identifiers

PMID40360460
PMCPMC12075465

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.