ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025
Bifunctional Chiral ImPy-Carbene Ligands. H-Bonding Controlled Reactivity and Enantioselectivity in Au(I)-Catalysis.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Spirosilanes Activate Gold(I)-Catalysts in Cycloisomerization and Intermolecular Reactions.Angewandte Chemie (International ed. in English) · 2026Article
- Chiral Imidazo[1,5‑JACS Au · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
Bifunctional chiral N-heterocyclic carbene ligands have been devised for enantioselective gold(I) catalysis. Based on a single C-stereogenic center derived from chiral pool α-aminoacids and connecting an imidazopyridine core to an arylurea motif, enantioselective gold(I)-catalyzed cycloisomerization reactions could be achieved. High enantioselectivities were notably observed for substrates presenting a pendant propargyl alcohol on 2-naphthol and 1,6-enyne scaffolds. In the latter case, the catalyst shows a high degree of selectivity for the unprecedented 6-endo-dig biscyclization of these substrates to give cyclopropyl-fused 6-ring heterocycles with a free OH functionality instead of the previously reported furan-fused products. This unusual selectivity was investigated by DFT studies, which suggested the dual role of the carbonyl group of the urea moiety: first as an H-bond acceptor in the catalytic cycle to direct the enantioselectivity and second as a cooperative group in the hydrogen shift leading to deauration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.