Evidence map›Paper›PMID 40360186›Full record

ArticleGenome research2025

Charting the regulatory landscape of TP53 on transposable elements in cancer.

Xuan Qu, Yonghao Liang, Colin McCornack, Xiaoyun Xing, Heather Schmidt, Chad Tomlinson, Catrina Fronick, Edward A Belter, Juan F Macias-Velasco, Ting Wang

Abstract read
In one paragraph

Article in Genome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xuan Qu *Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.ORCID 0000-0003-1436-3315
Yonghao Liang *Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.ORCID 0000-0002-1414-1256
Colin McCornackDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Xiaoyun XingDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Heather SchmidtDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Chad TomlinsonMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Catrina FronickMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Edward A BelterMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Juan F Macias-VelascoDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Ting WangDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA; twang@wustl.edu.ORCID 0000-0002-6800-242X

Funding

Washington University Omics Production CenterU01HG013227 · NHGRI · WASHINGTON UNIVERSITY · PI Gary J Patti, Ting Wang · 2023 to 2026
$11.1M
WashU Somatic Mosaicism across Human Tissues (SMaHT) Program Organizational CenterU24NS132103 · NINDS · WASHINGTON UNIVERSITY · PI FULTON, LUCINDA, LAWSON, HEATHER A. · 2023 to 2025
$4.5M
The role of retrotransposons in female reproductive agingR01AG078958 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI Lin He, Ting Wang · 2022 to 2026
$3.0M
DECODING THE IMPACT OF TRANSPOSABLE ELEMENTS ON GENE REGULATIONR01HG007175 · NHGRI · WASHINGTON UNIVERSITY · PI WANG, TING · 2014 to 2021
$2.7M
NHGRI NIH HHS R01 HG007175NHGRI NIH HHS U01 HG013227NIA NIH HHS R01 AG078958NINDS NIH HHS U24 NS132103
6 · The paper itself

Abstract

The relationship between TP53 and transposable elements (TEs) has been obscure. Given the important role of TEs in oncogenesis, a comprehensive profiling of TE expression dynamics under the regulation of TP53 provides valuable resources for more clarity in TP53's roles in cancer. In this study, we characterized the TE transcriptomic landscape using long-read RNA-seq and short-read RNA-seq in three cancer cell lines varying only in

Indexed as

DNA Transposable ElementsGene Expression Regulation, NeoplasticNeoplasmsTumor Suppressor Protein p53Cell Line, TumorHumansMutationPromoter Regions, GeneticTranscriptomeDNA Transposable ElementsTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID40360186
PMCPMC12129084

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.