Evidence map›Paper›PMID 40360082›Full record

ArticleNeuroscience research2025

Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task.

Jonathon Cavaleri, Shivani Sundaram, Roberto Martin Del Campo-Vera, Xiecheng Shao, Ryan S Chung, Miguel Parra, Adith Swarup, Selena Zhang, Alexandra Kammen, Angad Gogia and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jonathon CavaleriDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States. Electronic address: jonathon.cavaleri@med.usc.edu.
Shivani SundaramDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Roberto Martin Del Campo-VeraDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Xiecheng ShaoDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, United States.
Ryan S ChungDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Miguel ParraDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, United States.
Adith SwarupDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, United States.
Selena ZhangDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, United States.
Alexandra KammenDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Angad GogiaDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Xenos MasonDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Ryan McGinnDepartment of Neurology, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Christi HeckDepartment of Neurology, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, United States.
Charles Y LiuDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, United States; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, United States.
Spencer S KellisDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, United States; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, United States.
Brian LeeDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, United States; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, United States.

Funding

Decoding / encoding somatosensation from the hand area of the human primary somatosensory (S1) cortex for a closed-loop motor / sensory brain-machine interface (BMI)K23NS114190 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LEE, BRIAN · 2020 to 2024
$950k
USC Neurosurgery Research Education Training ProgramR25NS099008 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, WILLIAM J · 2017 to 2023
$516k
NINDS NIH HHS K23 NS114190NINDS NIH HHS R25 NS099008
6 · The paper itself

Abstract

The human amygdala is primarily known for its involvement in processing emotional and fearful responses, but newer evidence has identified a role for this structure in motor processing. Our lab previously utilized an arm-reaching task and observed significant beta-band (13-30 Hz) modulation in the hippocampus. Given these results, we sought to characterize the role of beta-band modulation in the amygdala during movement execution in participants with stereoelectroencephalography (SEEG) depth electrodes in the amygdala for seizure localization. We show that 9 of 13 participants (69.2 %) showed decreased beta-band power in the amygdala during the Response (movement execution) phase of an arm-reaching task when compared to Fixation (baseline). Secondary analyses show that there are no statistically significant differences in beta-band modulation between ipsilateral and contralateral implanted electrodes, but there is a small difference between male and female participants. The decrease in beta-band power in the amygdala during the Response phase of a Direct Reach task is consistent with our previous findings in the hippocampus. Our study is the first to report beta-band modulation in the amygdala during motor processing and sets the stage for further studies into the involvement of the amygdala in motor control.

Indexed as

AmygdalaArmBeta RhythmPsychomotor PerformanceAdultElectrodes, ImplantedElectroencephalographyFemaleHumansMaleMiddle AgedMovementYoung AdultAmygdalaBeta-band powerCenter-out arm reach taskLocal field potential (LFP)Non-emotional motor processingStereoelectroencephalography (SEEG)

Identifiers

PMID40360082
PMCPMC12288141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.