ArticleRetina (Philadelphia, Pa.)2025
Assessing Reliability and Agreement in Topographic Measurement of Reticular Pseudodrusen Area: A Multimodal Imaging Approach.
Article in Retina (Philadelphia, Pa.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aims to assess the reliability and agreement of fundus autofluorescence (FAF), near-infrared reflectance (NIR), and a combination of NIR and dense structural optical coherence tomography (OCT) scans (OCT+NIR) in delineating the areas of reticular pseudodrusen (RPD) in eyes affected by age-related macular degeneration (AMD).
methodsThis was a single-center, cross-sectional study. Patients with non-advanced AMD exhibiting signs of RPD on multimodal imaging were enrolled. Two independent masked graders manually delineated the margins of the area occupied by RPD using the three distinct imaging techniques.
resultsThe study included 60 eyes from 51 patients, with a mean age of 81.5 (±7.1) years.The intraclass correlation coefficient between the two graders across all imaging modalities was 0.96 for FAF, 0.92 for NIR, and 0.98 for OCT+NIR. The narrowest limits of agreement were observed with OCT+NIR (-4.38 +5.17 mm 2 ). Foveal involvement and age were significantly correlated with larger RPD area ( p =0.036 and p=0.019 respectively). Pairwise comparisons of square root-transformed RPD areas indicated that FAF detected a significantly larger RPD area compared to other methods ( p <0.001).
conclusionsThese findings validate OCT+NIR as a reliable approach for measuring RPD areas, potentially serving as a critical biomarker for AMD in future clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.