Evidence map›Paper›PMID 40359386›Full record

ArticleAnalytical chemistry2025

A Multipoint Validation of Quantification in Capillary Electrophoresis Mass Spectrometry Proteomics: Isobaric Multiplexing with Tandem Mass Tags.

Laura G Rodriguez, Camille Lombard-Banek, Vi M Quach, Sam B Choi, M Chiara Manzini, Peter Nemes

Abstract readValidation Study
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laura G RodriguezDepartment of Chemistry & Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
Camille Lombard-BanekDepartment of Chemistry & Biochemistry, University of Maryland, College Park, Maryland 20742, United States.ORCID 0000-0003-0438-1042
Vi M QuachDepartment of Chemistry & Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
Sam B ChoiDepartment of Chemistry & Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
M Chiara ManziniDepartment of Pharmacology & Physiology, The George Washington School of Medicine and Health Sciences, Washington, District of Columbia 20032, United States.
Peter NemesDepartment of Chemistry, The George Washington University, Washington, District of Columbia 20052, United States.ORCID 0000-0002-4704-4997

Funding

Sub-Cellular Mass Spectrometry Discoveries: Metabolic Encoding of the Embryonic Body PlanR35GM124755 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI Peter Nemes · 2017 to 2026
$3.8M
Ultrahigh-Sensitivity Mass Spectrometry for Scalable ProteomicsR01AG088147 · NIA · UNIV OF MARYLAND, COLLEGE PARK · PI Peter Nemes · 2024 to 2026
$1.8M
Microanalytical Peptide-Peptidase Profiling of the Brain Renin-Angiotensin System in a Genetically Diverse Alzheimer's Disease Mouse ModelR21AG086859 · NIA · UNIV OF MARYLAND, COLLEGE PARK · PI MARVAR, PAUL J, NEMES, PETER · 2024 to 2024
$443k
NIA NIH HHS R01 AG088147NIA NIH HHS R21 AG086859NIGMS NIH HHS R35 GM124755
6 · The paper itself

Abstract

Multiplexing quantification using isobaric barcoding has gained traction in trace-sensitive and single-cell mass spectrometry (MS), both in nanoflow liquid chromatography (nanoLC) and capillary electrophoresis (CE). In nanoLC-MS, ratio compression from isobaric interferences is known to challenge quantification accuracy during tandem MS (MS

Indexed as

ProteomeProteomicsTandem Mass SpectrometryAnimalsElectrophoresis, CapillaryMicePeptidesReproducibility of ResultsSaccharomyces cerevisiaePeptidesProteome

Identifiers

PMID40359386
PMCPMC12798853

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.